Session: S34-Genetic Control of Arcuate Hypothalamic Development, Differentiation and Renewal
Room 206 (Moscone Center)
We identify a neural progenitor population along the ependymal layer of the hypothalamic median eminence (ME) of postnatal mice, which we term the hypothalamic proliferative zone (HPZ). Dividing cells within this niche are β2 tanycytes and give rise to neurons in vivo, displaying substantially higher levels of neurogenesis than other hypothalamic regions. ME neurogenesis is enhanced in response to a high-fat diet in both postnatal and adult mice, and the newly generated neurons are activated by dietary signals. Furthermore, when focal irradiation is used to block neurogenesis within ME, irradiated mice showed attenuated weight gain compared to sham controls. These findings demonstrate the existence of a previously unreported neurogenic niche within the mammalian hypothalamus, with important implications for studies of feeding and metabolism.
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