S24-2 Hormonal Regulation of FGF23 by Vitamin D, PTH and Phosphate

Program: Symposia
Session: S24-FGF23: New Insight on Regulation in Humans and Murine Models
Basic
Sunday, June 16, 2013: 9:00 AM-10:30 AM
Presentation Start Time: 9:30 AM
Room 102 (Moscone Center)
Sherri-Ann M Burnett-Bowie*
Massachusetts General Hospital, Boston, MA
Talk Description:

Fibroblast growth factor 23 (FGF23) is a peptide hormone essential for phosphate (PO4) and vitamin D metabolism. Abnormal FGF23 physiology contributes to the morbidity of many common diseases (e.g. chronic kidney disease and cardiovascular disease) and causes rare disorders (e.g. inherited and acquired forms of hypophosphatemic rickets or osteomalacia). Basic and clinical studies have been critical to defining the roles of dietary PO4, serum PO4, 1,25-dihydroxyvitamin D (1,25(OH)2D), and parathyroid hormone (PTH) in FGF23 regulation. In this session, human studies of FGF23 physiology in health and disease states will be reviewed. Specifically, the regulation of FGF23 by dietary and serum PO4, 1,25(OH)2D, and PTH will be discussed.