Session: S47-Food Addiction
Room 301 (Moscone Center)
An overload of saturated fat and sugar increases the risk to develop obesity. Many animal models of obesity are directed at increasing weight gain, however do not reflect the eating patterns observed in many obese individuals who frequently snack high fat-sugar items. Interestingly, we recently showed that rats mainly overeat when consuming frequent meals with high fat-sugar content. Moreover, these rats are more motivated to work for a reward. The observed increased snacking and motivation are clearly reflected in the brain, with increased orexigenic signals in hypothalamus and increased motivational signaling in cortico-limbic areas. To determine whether also in humans specific macronutrients and eating patterns affect the brain, we performed an experiment in young male subjects subjected to a hypercaloric diet for 6 weeks. During my talk, I will show the effects of both macronutrient content and eating pattern during this hypercaloric period on the brain serotonin and dopamine systems.