Session: S38-Obesity and Dysregulated Sleep
Supported by VIVUS, Inc.
Room 135 (Moscone Center)
The circadian system coordinates sleep-wake cycle and 24 hr physiologic patterns in synchrony with the rotation of the Earth. Clock genes are expressed in both pacemaker cells of the hypothalamus and within nearly all peripheral cells where they control glucose metabolism and energetics. A major function of the clock involves the maintenance of energy constancy within different tissues at different phases of the sleep-wake cycle. This presentation will present evidence for a role of local tissue clocks in both glycolytic and oxidative metabolism and the molecular basis for the temporal integration of these processes.