Session: S13-Evolution of Nuclear Receptors
Room 256 (Moscone Center)
We are using Drosophila as a model system to define the molecular mechanisms of metabolic control and to better understand the causes of metabolic disorders. There are three projects currently underway in the lab. The first is focused on how nuclear receptors sense small metabolites and regulate the transcription of genes that play central roles in specific metabolic pathways. These studies currently address how dHNF4 regulates carbohydrate homeostasis and contributes to a late onset form of diabetes known as MODY1, the role of dERR in promoting aerobic glycolysis to support developmental growth, and the control of lipid metabolism by DHR78 and DHR96. The other two projects are aimed at defining the functions of uncharacterized mitochondrial proteins that are conserved through evolution from yeast to humans, and studies of the transgenerational inheritance of metabolic state.