S31-3 Androgen Receptor Collaborating Transcription Factors in Prostate Cancer

Program: Symposia
Session: S31-AR and Coactivators in Prostate Cancer
Basic
Sunday, June 16, 2013: 4:00 PM-5:30 PM
Presentation Start Time: 5:00 PM
Room 256 (Moscone Center)
Olli A Janne*
University of Helsinki, Helsinki, Finland
Talk Description:

High androgen receptor (AR) level in primary tumor predicts increased prostate cancer-specific mortality. The presentation will deal with transcription factors that influence the AR pathway in prostate cancer and outcome of the disease. The forkhead protein FoxA1 is a pioneer factor for AR but has other functions as well. Its depletion elicits significant redistribution of AR and glucocorticoid receptor (GR) cistromes. There are distinct classes of AR-binding events and androgen-responsive genes; (i) independent of FoxA1, (ii) pioneered by FoxA1, and (iii) masked by FoxA1. FoxA1 protein level in primary prostate tumor has significant association to disease outcome; high FoxA1 level predicts poor and low FoxA1 level good prognosis of the disease. AR and GR cistromes and transcription programs exhibit significant overlap, and GR regulates a large number of genes considered as AR pathway-specific. GR is potentially able to maintain the AR pathway under androgen-deprived conditions in castration-resistant prostate cancer patients

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