Session: S63-Pituitary Tumorigenesis
Room 304 (Moscone Center)
Mouse Models for Multiple Endocrine Neoplasia Type 1 (MEN1) R.V. Thakker, May Professor of Medicine, University of Oxford, Nuffield Department of Clinical Medicine, OCDEM, Churchill Hospital, Headington, Oxford, OX3 7LJ, UK. Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease characterised by tumours of the parathyroids, pancreatic islets and anterior pituitary. In addition, some patients may develop adrenal cortical tumours, carcinoid, facial angiofibromas, collagenomas, and lipomas. The gene causing MEN1 is located on chromosome 11q13 and encodes a 610 amino acid tumour suppressor protein, menin. Mouse models have been developed for MEN1 by homologous recombination methods that delete an Men1 allele. Thus, Men1+/- mice develop multiple tumours in a time-dependent manner beginning around 9 months of age, of the parathyroids, pancreatic islets, anterior pituitary, adrenals and gonads as well as lipomas. Studies of Men1+/- mice developing these tumours have provided important insights in endocrine tumourigenesis and the possible role of gene replacement therapy for the treatment of endocrine tumours.