Session: S36-Islet Cells: Bench to Bedside
Room 134 (Moscone Center)
Islet transplantation has demonstrated that cell replacement therapy for diabetes can be a successful approach for the treatment of type 1 diabetes. Some of the remaining challenges for islet transplantation and cell replacement therapy will be reviewed. The approach of our research team to develop bioactive scaffolds capable of serving as a platform for islet transplantation will be discussed. This will include the use of an alternative site of islet transplantation in murine models of diabetes as well as approaches for modifying the microenvironment of the islets through the application of extracellular matrix proteins to the scaffold or the release of bioactive peptides from the scaffold. Finally, translation of the approach to large animal models and transplantation of human islets on the scaffold will be presented.