Session: S46-Coregulators and Nuclear Receptor Action
Room 121 (Moscone Center)
Androgen receptor (AR) is a member of the ligand activated transcription factor family. Its function is regulated by a complex network of coregulatory proteins and cell signaling pathways. AR is a key transcription factor in healthy prostate function and during neoplastic transformation. In normal prostate, it regulates prostate secretory function, stimulates epithelial cell renewal, and maintains the cells in a differentiated state. However, under certain circumstances AR function loses its differentiating thrust and proliferative function becomes dominant. AR transcriptome, cistrome, and ligand requirements change during prostate cancer development and progression. Altered coregulator expression and activity may contribute to shift in AR action and play a major role in development of castration resistant prostate cancer. In this presentation, I will discuss promoter-specific effects of several coregulators on AR mediated activation and repression.