Session: S69-Functional Hypothalamic Amenorrhea: Special Topics
Room 134 (Moscone Center)
Coexistence of Functional Hypothalamic Amenorrhea and PCOS Hypothalamic amenorrhea (HA) is a secondary amenorrhea mainly associated with stressors such as low dietary intake, intensive physical exercise or severe psychological stress. Many of the women also have hypoestrogenism, which during a prolonged period of time results in significant loss in bone mass density and metabolic changes. Women with HA have low or normal serum gonadotropins. Even more prevalent than HA is polycystic ovary syndrome (PCOS), the most common endocrinopathy of reproductive-aged women that affects 5% to 8% of women. Women with PCOS tend to have increased circulating levels of LH and androgens. Although HA and PCOS are the most frequent causes of hormonal infertility, their association is not commonly reported. The uncovering of “hidden” PCOS has been reported after GnRH and gonadotropin administration. HA with underlying PCOS is not as uncommon an association as the lack of reports suggests and there are implications with respect to bone loss and recovery of menstrual function.
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