S70-1 Biochemical Evaluation of Pheochromocytoma

Program: Symposia
Session: S70-Neuroendocrine Tumors: New Tools for Diagnosis and Management
Clinical
Supported by Ipsen Biopharmaceuticals, Inc.
Tuesday, June 18, 2013: 7:30 AM-9:00 AM
Presentation Start Time: 7:30 AM
Room 104 (Moscone Center)
Jacques W.M. Lenders*
Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Talk Description:

In this presentation, an overview will be presented on the current biochemical methods to exclude or to confirm a catecholamine-producing chromaffin cell tumor. In view of the potential fatal consequences of missing this tumor, a test with a nearly 100% negative predictive value is necessary to exclude reliably the presence of this tumor. Currently there is overwhelming evidence that measurement of metanephrines, either in urine or plasma, offers tests with a sensitivity higher than 95%. Specifity is suboptimal, indicating additional necessary testing in case of slightly elevated test results of plasma or urinary metanephrines. In addition to these test characteristics, pre-analytical test conditions for sampling of blood or urine will be addressed. Specific attention will be given to the use of appropriate reference intervals since these are critical for correct interpretation of test results.

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