S59-3 The Role of Activin Signaling in Obesity and Insulin Sensitivity

Program: Symposia
Session: S59-Growth Factors in the BAT-tle against Obesity
Monday, June 17, 2013: 4:00 PM-5:30 PM
Presentation Start Time: 5:00 PM
Room 303 (Moscone Center)
Jennifer Lachey*
Acceleron Pharma, Cambridge, MA
Talk Description:

The transforming growth factor beta (TGFb) superfamily plays an essential role in the development and homeostasis of adipose tissues, and regulation of these family members provides an interesting opportunity for the development of obesity and diabetes therapeutics. Both the classic brown fat depot and white fat-resident beige cells which can be recruited to a brown fat-like phenotype have the capacity to burn energy as heat, an effect that could potentially compensate for the excess caloric intake associated with diet induced obesity. This presentation will focus on ligands and antagonists of this important superfamily and their effects on brown fat biology and/or ability to promote a brown fat phenotype in white adipose depots. Understanding the effect of these biologics on increasing energy expenditure could provide support for their development in the treatment of obesity and diabetes.

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