Gerald D. Aurbach Award Lecture: Circadian Epigenomic Regulation of Metabolism

Program: Plenary
Session: L2-1-Gerald D. Aurbach Award Lecture: Circadian Epigenomic Regulation of Metabolism
Basic
Saturday, June 15, 2013: 5:55 PM-6:20 PM
Presentation Start Time: 5:55 PM
Hall D (Moscone Center)
Mitchell A Lazar*
University of Pennsylvania
Talk Description:

Many endocrine processes are circadian, and disturbances of normal rhythms can disrupt metabolism. Underlying these rhythms are molecular clocks, consisting of interdependent transcriptional feedback loops. The clock components, including nuclear heme receptors Rev-erbα and β, bind throughout the genome with coregulators that modify chromatin to rhythmically modulate gene expression in tissues. These circadian epigenomic rhythms orchestrate daily cycles of lipid and glucose metabolism that are required for normal physiology.