S19-3 Biogenesis and Clinical Potential of Tumor-Derived Microvesicles

Program: Symposia
Session: S19-Microvesicles and Exosomes as Intercellular Communicators
Basic
Saturday, June 15, 2013: 4:00 PM-5:30 PM
Presentation Start Time: 5:00 PM
Room 303 (Moscone Center)
Crislyn D'Souza-Schorey*
University of Notre Dame, Notre Dame, IN
Talk Description:

Recent developments in the study of tumor-derived microvesicles reveal new insights into the cellular basis of disease progression and the potential to translate this knowledge into innovative approaches for cancer diagnostics and personalized therapy. Tumor-derived microvesicles are heterogeneous membrane-bound sacs that are shed from the surfaces of tumor cells into the extracellular environment. The formation of these shed vesicles likely involves both, a redistribution of surface lipids and the vertical trafficking of cargo to sites of microvesicle biogenesis at the cell surface. The complexity of their bioactive cargo, which includes proteins and nucleic acids, suggests multi-pronged mechanisms by which microvesicles can condition the extracellular milieu to facilitate disease progression.

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