Increased Plasma Renin Level but not Angiotensin Converting Enzyme Activity in Patients with Polycystic Ovary Syndrome

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 554-573-Ovarian & Uterine Function I
Basic/Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-559
Ziynet Alphan ÜÇ*1, Süheyla Görar1, Zehra Berberoglu1, Zehra Candan1, Fatma Dilek Dellal2, Aynur Aktas1, Handan Bekdemir3, Esranur Ademoglu1 and Yalçın Aral1
1Ankara Training and Research Hospital, Ankara, Turkey, 2Agri Government Hospital, Agri, Turkey, 3Ankara Training and Research Hospital, Turkey
Abstract

Objective:One of the hallmarks of polycystic ovarian syndrome (PCOS) is insulin resistance.Activation of Renin-Angiotensin-Aldosteron system ( RAAS) is linked to impaired insülin signalling and insülin rezistance is classic target tissues such as skeletal muscle and liver, as well as in non-classic target tissues for insulin action, including cardiac, vascular , ovarian and renal tissues.

The identification of the presence of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin II (Ang II), and Ang II receptors in the ovary suggests that there is a functional ovarian renin-angiotensin system (RAS).Disturbances in the ovarian RAS can be the cause or the result of such reproductive disorders as polycystic ovary syndrome.

Renin-angiotensin-aldosterone system may be involved in the pathogenesis of insulin resistance via oxidative stres. Therefore, we aimed to investigate renin-angiotensin-aldosterone system and angiotensin-converting enzyme (ACE) activity in patients with PCOS.

Subjects and Methods:In this case–control study, 41 obese PCOS women and 29 healthy controls matched for age and body mass index were enrolled. Anthropometric, metabolic, and hormonal  patterns, including plasma aldosterone and renin, ACE activity, were measured in each subject.Insülin resistance which was calculated  as HOMA-IR was to evaluate in the groups and it was to be accepted significant ≥2.7.Aldosteron, renin , ACE levels were compared about the groups of PCOS and non-PCOS obese patients.

Results: Plasma renin and aldosterone levels were significantly higher in PCOS compared with controls (p< 0.05). ACE activity did not significantly differ between both groups. Analysis of  PCOS patients showed a significant correlation of fasting insulin levels with levels of renin (r = 0.305, p = <0.01), and free testosterone (r = 0.384, p = 0.001).

Conclusion:

RAAS activation  showed in PCOS patients as the other many studies.Although  serum ACE level wasn’t evaluated as a predictive factor the increase of aldosteron and renin levels was found and RAAS activation was showed as a etiology of PCOS. Further studies which have larger sample size are needed. .Further studies which have larger sample size are needed.

Nothing to Disclose: ZA, SG, ZB, ZC, FDD, AA, HB, EA, YA

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm