Session: SUN 554-573-Ovarian & Uterine Function I
Poster Board SUN-559
Objective:One of the hallmarks of polycystic ovarian syndrome (PCOS) is insulin resistance.Activation of Renin-Angiotensin-Aldosteron system ( RAAS) is linked to impaired insülin signalling and insülin rezistance is classic target tissues such as skeletal muscle and liver, as well as in non-classic target tissues for insulin action, including cardiac, vascular , ovarian and renal tissues.
The identification of the presence of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin II (Ang II), and Ang II receptors in the ovary suggests that there is a functional ovarian renin-angiotensin system (RAS).Disturbances in the ovarian RAS can be the cause or the result of such reproductive disorders as polycystic ovary syndrome.
Renin-angiotensin-aldosterone system may be involved in the pathogenesis of insulin resistance via oxidative stres. Therefore, we aimed to investigate renin-angiotensin-aldosterone system and angiotensin-converting enzyme (ACE) activity in patients with PCOS.
Subjects and Methods:In this case–control study, 41 obese PCOS women and 29 healthy controls matched for age and body mass index were enrolled. Anthropometric, metabolic, and hormonal patterns, including plasma aldosterone and renin, ACE activity, were measured in each subject.Insülin resistance which was calculated as HOMA-IR was to evaluate in the groups and it was to be accepted significant ≥2.7.Aldosteron, renin , ACE levels were compared about the groups of PCOS and non-PCOS obese patients.
Results: Plasma renin and aldosterone levels were significantly higher in PCOS compared with controls (p< 0.05). ACE activity did not significantly differ between both groups. Analysis of PCOS patients showed a significant correlation of fasting insulin levels with levels of renin (r = 0.305, p = <0.01), and free testosterone (r = 0.384, p = 0.001).
RAAS activation showed in PCOS patients as the other many studies.Although serum ACE level wasn’t evaluated as a predictive factor the increase of aldosteron and renin levels was found and RAAS activation was showed as a etiology of PCOS. Further studies which have larger sample size are needed. .Further studies which have larger sample size are needed.
Nothing to Disclose: ZA, SG, ZB, ZC, FDD, AA, HB, EA, YA
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