Changes in Risk Factors for the Metabolic Syndrome as a Result of Ten Weeks of High Sugar Intake Are Not Impacted by the Type or Amount of Fructose Containing Sugar Consumed

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 758-775-Beta Cells, Glucose Control & Complications
Basic/Translational
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-772
Joshua Lowndes*, Stephanie Sinnett, Zhiping Fullerton and James Marshall Rippe
Rippe Lifestyle Institution, Celebration, FL
The purpose of this study was to investigate the dose response effect of fructose containing dietary sugars.

355 overweight or obese individuals aged 20-60 years old incorporated 1% fat milk sweetened with either sucrose or high fructose corn syrup into their usual diet for ten weeks.  Consumption levels were set so the added sugar contributed 8%, 18%, or 30% of calories required for weight maintenance (25th, 50th or 90th percentile of adult fructose consumption levels, resepctively).

Triglyceride levels increased slightly (104.1± 51.8 vs 114.1 ± 64.7 mg/dl, p<0.001), as did waist circumference (84.7 ± 9.8 vs 85.0 ± 10.0cm, p<0.05) in the entire pooled cohort along with a decrease in HDL (52.4 ± 14.1 vs 51.6 ± 13.6 mg/dl p<0.05).  Blood pressure and fasting glucose were unchanged.  The amount or type of sugar did not affect any of the observed responses (interaction p>0.05).

These short term data show that these levels of high sugar intake can lead to small increases in some risk factors for the metabolic syndrome.  However, there were no differences between the two most common types of fructose containing sugars at any level of intake.

Nothing to Disclose: JL, SS, ZF, JMR

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Funding from the Corn Refiners Association Funding from the Corn Refiners Association