OR51-5 Obese adolescents and allergic disease: Is there a role for adipokines and Vitamin D?

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: OR51-Obesity: From Genes to Populations
Tuesday, June 18, 2013: 9:15 AM-10:45 AM
Presentation Start Time: 10:15 AM
Room 303 (Moscone Center)
Candace Suzanne Staubitz Percival*1, David Larson2, Noelle Summers Larson3, Jill Ellen Emerick4, Karen Susan Vogt5, Cara H Olsen6 and Merrily Poth2
1USUHS, Rockville, MD, 2USUHS, Bethesda, MD, 3WRNMMCB, 4WRNMMC, MD, 5Walter Reed National Military Me, Burtonsville, MD, 6Uniformed Services University of Health Sciences, Bethesda, MD
Obesity, a risk factor for metabolic syndrome, diabetes and heart disease, is also associated with increased allergic disease; a relationship that is not well understood.  One in vitro study reported that the adipokine, leptin, elevated in obesity, directly activated and primed human basophils, a cell type known to be involved in the allergic response.  Another adipokine, adiponectin, is lower in obese subjects, and enhancement of allergic airway inflammation was seen in a mouse model of adiponectin deficiency.  We hypothesized that variations in leptin and adiponectin levels with increasing BMI, would positively correlate with  serum IgE , type 2 cytokine levels (as demonstrated by IL-4, IL-13, and IL-6) and basophil number and reactivity.

This was an observational cross-sectional study of overweight and control adolescents to elucidate mechanisms for increased allergy in obesity. We evaluated the relationship among BMI-Z score and plasma leptin, adiponectin, IgE, vitamin D, basophil number and responsiveness and type 2 cytokine levels.  

Adipokines were evaluated in 58 subjects and cytokines assessed in 33. As expected, BMI-Z score was positively correlated (p<0.001) with plasma leptin and negatively correlated with plasma adiponectin and vitamin D (p=0.007, p<0.001 respectively).   In our population, positive correlations were found between BMI-Z score and IgE (p=0.045), IL-6 (p=0.013), and IL-13 (p=0.023).  IL-4 did not correlate with BMI-Z score, leptin, or adiponectin.  Basophil number and reactivity were not correlated with leptin or adiponectin. Analyzing vitamin D as a co-variable with BMI-Z score and cytokines resulted in elimination of all significant correlations.

Our data confirm previously reported correlations between BMI and low adiponectin, high leptin, and high IL-6.  Our findings that IL-13 and IgE levels correlate with BMI-Z scores are consistent with increased allergic disease in obese subjects.  Contrary to our hypothesis, neither BMI nor adipokine levels were associated with basophil number, reactivity, or IL-4 in vivo.  Of interest, when vitamin D was entered in a multivariate analysis, the positive correlations between cytokines and IgE with BMI-Z score disappeared.  Further investigation of the role of other cell types involved in the allergic immune response and their association with vitamin D, may provide further insight into the mechanism of obesity associated allergy.    

Nothing to Disclose: CSSP, DL, NSL, JEE, KSV, CHO, MP

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm