Session: SAT 697-707-Obesity Pathophysiology
Poster Board SAT-701
Study subject/measurements Two hundred ninety eight (male: 119, female: 179) adults aged 20 - 70 years were examined using dual X-ray absorptiometry and computed tomography (CT). Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by weight (%) of < 1 SD below the mean values of young adults in both sexes. Obesity was defined as visceral fat area (VFA) ≥ 100 cm2 using abdominal CT. Serum A-FABP levels were measured using an enzyme-linked immunosorbent assay.
Results Serum A-FABP levels were higher in groups with SO compared to non-SO groups in both men and women. In the unadjusted model, serum A-FABP levels were positively associated with VFA and negatively associated with ASM/weight. Even after adjusting for possible confounding factors, including age, gender, BMI, blood pressure, lipid profile, HOMA-IR, hsCRP, IL-6, TNF-α, adiponectin, and leptin, ASM/weight was found to be independently and negatively associated with serum A-FABP levels (P = 0.013). In addition, multiple logistic regression analysis showed that increased serum levels of A-FABP were independently associated with the presence of SO.
Conclusion The present findings indicate that serum A-FABP levels may be valuable markers of the presence of SO.
Nothing to Disclose: TNK, JCW, EJL
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