Obesity explains the reduced quality of life found in polycystic ovary syndrome

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 532-553-Hyperandrogenic Disorders
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-542
Hassan Kahal*1, Marie Reid2, Anne Marie Coady3, Eric S Kilpatrick3 and Stephen Lawrence Atkin4
1Hull York Medical School, Hull, United Kingdom, 2University of Hull, Hull, United Kingdom, 3Hull and East Yorkshire NHS Trust, Hull, United Kingdom, 4Hull York Medical School, E Yorkshire, United Kingdom
Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, and is associated with conditions that may have a negative impact on quality of life (QoL) including hirsutism, oligomenorrhoea, obesity and sub-fertility. PCOS has been associated with depression and reduced QoL in several studies. We hypothesized that PCOS was independently associated with reduced QoL and depression, when obesity was controlled for.

Methods: A case-control study of obese women with PCOS, none of whom wanted fertility, and age and weight matched controls. PCOS was diagnosed according to the Rotterdam criteria. Depression was measured using the Centre for Epidemiologic Studies Depression Scale (CES-D). An average score of ≥16 on this scale suggests a high risk for depression. QoL was measured using the short version of the World Health Organization QOL questionnaire (WHOQOL-BREF) which includes four subscales (physical, psychological, social and environment). Scores are given out of a hundred and higher scores are better. Data presented as mean ±SD.

Results: 37 women were recruited (20 PCOS, 17 controls), age33.3±7.1 vs. 33.5±7.1 years, weight 101.1±17.1 vs.100.4±15.2 kg, BMI 37.6±5 vs. 36.5±4.6 kg/m2, and waist 111.9±12.7 vs. 112.4±9.4 cm, respectively (all P>0.05). The PCOS group had higher testosterone 1.3±0.3 vs. 0.9±0.3 nmol/L (P<0.01), free androgen index 4.3±1.9 vs. 2.7±1.3 (P=0.01) and HOMA-IR 2.5±1.7 vs. 1.7±1.0 (P=0.08). Fifteen (75%) women with PCOS vs. three (17.7%), P<0.01, of controls complained of hirsutism. The average number of periods per year was 6.1 (±3.6) vs. 12, for PCOS and controls, respectively.

There was no significant difference between the PCOS and controls on the CES-D with six (30%) vs. five (29.4%), P=0.97, women having scores ≥ 16 suggestive of depression, respectively. Similarly, there was no difference on the WHOQOL-BREF questionnaire, physical health 80.5%±12.5 vs. 77.3%±14.6 (P= 0.48); psychological health 60.2%±10. vs. 55.6%±621.9 (P=0.41); social relationships 74.7%±13 vs. 68%±20.5 (P=0.24); or environment 72±12.1 vs. 73.3±16.9 (P=0.78) for PCOS and controls, respectively.

Conclusions: When matched for age and obesity, PCOS was not independently associated with reduced QoL and depression, suggesting that obesity had the greatest impact on these parameters.

Nothing to Disclose: HK, MR, AMC, ESK, SLA

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm