A Prospective Observational Trial Comparing Minimally Invasive Video-Assisted Parathyroidectomy with Traditional Parathyroidectomy for Sporadic Primary Hyperparathyroidism

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 234-256-Bone & Calcium Metabolism: Clinical Trials & Case Series
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-239
Paolo Del Rio1, Diego Vicente*2, Umberto Maestroni1, Anna Totaro1, Gian Pattacini1, Itzhak Avital3, Alexander Stojadinovic4 and Mario Sianesi1
1University Hospital of Parma, 2Walter Reed National Military Medical Center, 3Bon Secours Cancer Institute, Richmond, VA, 4Walter Reed National Military Medical Center, Bethesda, MD
A Prospective Observational Trial Comparing Minimally Invasive Video-Assisted Parathyroidecotmy with Traditional Parathyroidectomy for Sporadic Primary Hyperparathyroidism

Paolo Del Rio1, Diego Vicente2, Umberto Maestroni1, Anna Totaro1, Gian Maria  Casoni Pattacini1, Itzhak Avital3, Alexander Stojadinovic2,4,5, Mario  Sianesi1

1 Department of Surgery -University Hospital of Parma

2 Department of Surgery, Walter Reed National Military Medical Center, Bethesda, MD

3 Bon Secours Cancer Institute, Richmond, VA

4 United States Military Cancer Institute, Bethesda, MD

5 Uniformed Services University of the Health Sciences, Bethesda, MD

Abstract

Background: Pre-operative imaging techniques for sporadic primary hyperparathyroidism (SPHPT) and intraoperative parathyroid hormone (ioPTH) have led to the wide spread use of minimally invasive surgical approaches.

Methods: In this prospective observational trial, 157 subjects with SPHPT and a preoperative diagnosis of parathyroid adenoma were treated with parathyroidectomy between January 2003 and November 2011.  Subjects in group A were enrolled between January 2003 to September 2006, and underwent traditional parathyroidectomy with intraoperative frozen section and bilateral neck exploration.  Subjects in group B were enrolled between September 2006 to November 2011, and underwent minimally invasive video-assisted parathyroidectomy (MIVAP) with ioPTH.  Operative times and post-operative pain levels were compared between groups.  Subjects were followed for a minimum of 6 months post-operatively and recurrence rates and complication rates were measured between groups.

Results: 81 patients were enrolled in group A, and 76 were enrolled in group B.  Pre-operative evaluation demonstrated that the groups were statistically similar.  Significantly decreased operative times (28min vs. 62min) and post-operative pain levels were noted in group B.  Recurrence rates were similar between group A (3.7%) and group B (2.6%).

Conclusions: MIVAP with ioPTH demonstrated significantly improved operative times and post-operative pain levels, while maintaining equivalent recurrence rates.

Nothing to Disclose: PD, DV, UM, AT, GP, IA, AS, MS

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm