Session: MON 649-675-Central Regulation of Appetite & Feeding/GI Regulatory Peptides
Bench to Bedside
Poster Board MON-656
Objective: To determine the effect of a 6-month trial of exenatide on appetite and weight in youth with PWS.
Methods: Ten overweight subjects with PWS (13-25 years) were recruited for an open-label, non-randomized, 6-month longitudinal exenatide trial starting at a dose of 5 mcg SQ BID with an increase to 10 mcg SQ BID after 1 month. Primary outcome measures were weight, BMI, body composition, appetite, and serum measurements of gut hormones, including acylated ghrelin. Subjects were followed with appetite questionnaires, meal tolerance tests, DEXA scans, and anthropometrics. No dietary modifications were made during the study. Data are presented as mean + SD and differences between groups assessed by paired t-tests. In addition, drug safety was closely monitored.
Results: Preliminary analyses show that total appetite scores significantly decreased from 29.6 ± 6.42 to 24.78 ± 7.50 after 1 month of exenatide (p=0.002) and to 19.33 ± 8.43 after 3 months of treatment (p=0.015). However, no significant changes in weight or BMI were noted from baseline after 1 month (weight +0.63 ± 1.49 kg, p=0.24; BMI +0.13 ± 0.84 kg/m2, p=0.66) or 3 months (weight +1.52 ± 2.95 kg, p=0.26; BMI +0.36 ± 1.00 kg/m2, p=0.42) of treatment. Analysis of gut hormones is pending batch analysis. Exenatide was well-tolerated without major adverse effects.
Conclusion: Exenatide appears to be safe and effective in decreasing appetite in youth with PWS, although it did not decrease weight or BMI in the short term. Larger, controlled, longer-term trials are needed to confirm the safety and efficacy of exenatide, and to evaluate whether its use might induce weight loss when used in conjunction with behavioral modification.
Nothing to Disclose: PS, SDM, MEG, DDJ
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