Ten Weeks of Daily Consumption of Common Fructose Containing Sugars Does Not Increase Ectopic Muscle Fat Deposits

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 695-707-Obesity Treatment
Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-703
Stephen Bravo*1, Joshua Lowndes2, Zhiping Fullerton2 and James Marshall Rippe2
1Sand Lake Imaging, Orlando, FL, 2Rippe Lifestyle Institution, Celebration, FL
Background: Fructose induced triglyceride synthesis has been argued to be augmented when accompanied by glucose.  As the most common sources of fructose, high fructose corn syrup (HFCS) and sucrose, also contain glucose such a response would be particularly detrimental to metabolic health due to the known role of excess fat in the skeletal muscle in the induction of insulin resistance and the subsequent development of type 2 diabetes.

Method: For ten weeks, sixty-eight individuals (42.16 ± 11.66 years) consumed low-fat milk sweetened with either HFCS or sucrose such that the added sugar matched the 25th, 50th and 90th percentile population consumption levels of fructose.  Fat content of the vastus lateralis (VL) and gluteus maximus (GM) was obtained before and after the ten week intervention.  Images were obtained on a Philips Intera 1.5 T magnet.  Signal intensity measurements were converted to grams of fat per mL or musculature.  

Results: Fat content of both the VL (3.07 ± 0.74 vs 3.15 ± 0.84g/100ml) and GM (4.08 ± 1.50 vs 4.24 ± 1.42g/100ml) were unchanged over the ten weeks (p<0.05).  Group assignment did not affect the result (interaction > 0.05).

Conclusions: These short-term data suggest that ectopic fat deposition in skeletal muscles is not promoted by fructose when consumed for ten weeks as part of a normal diet, even in amounts as high as the 90th percentile consumption level.

Nothing to Disclose: SB, JL, ZF, JMR

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm