Session: SUN 130-162-Neuroendocrinology
Poster Board SUN-138
Aims: We compared clinical characteristics of KIMS patients with COCP with & without DI, & those who underwent CT regimens of the tumor to those that underwent only 1 surgery (1Sg).
Methods: Data from 180 COCP patients were analyzed.
Results: Overall, more patients had DI (n=140, 77.8%) than no DI (n=40, 22.2%), & more patients underwent 1Sg (n=107, 59.4%) than CT (n=73, 40.6%). There were no gender differences between the DI (91M/49F) & no DI (20M/20F), & between the CT (51M/22F) & 1Sg (60M/47F) groups.
A) DI vs no DI: Compared to patients without DI, those with DI had similarly impaired quality of life (QoL) (QoL AGHDA scores: 10.1±6.3 vs 8.6±7.3; normal 3.8-6.7), but higher BMIs (30.4±8.1 vs 26.5±6.3 kg/m2; P=0.008). More patients with DI had ACTH (97.1% vs 82.5; P<0.001), TSH (100% vs 92.5%; P=0.001) & gonadotropin (98.6% vs 90.0%; P=0.008) deficits, but both groups had comparable rates of visual field defect (VFD) & ophthalmoplegia.
B) CT vs 1Sg: In the CT group, 52 (71.2%) patients underwent 2 surgeries & 21 (28.8%) patients underwent ≥3 surgeries, while 45 (61.6%) patients did not undergo cranial radiotherapy & 28 (38.4%) patients underwent ≥1 cranial radiotherapy that was mainly external & stereotactic radiotherapy (85.7%). Comparable numbers of patients underwent transcranial surgery in the CT & 1Sg (76.4% vs 78.3%) groups. Compared to the 1Sg group, the CT group had similarly impaired QoL (QoL AGHDA scores: 10.4±6.0 vs 9.3±6.8), but higher BMIs (30.7±7.4 vs 28.8±8.2 kg/m2; P=0.03). Comparable numbers of patients had ACTH, TSH, gonadotropin & ADH (79.5% vs 77.1%) deficits, but more patients in the CT group had VFD (70.4% vs 44.3%; P=0.003) & ophthalmoplegia (22.5% vs 5.4%; P=0.005).
Conclusion: Despite more COCP patients undergoing 1Sg than CT, the majority of patients in both groups had DI suggesting that even 1Sg may adversely affect the neurohypophyseal system possibly by extensive transcranial surgery. The presence of DI is associated with higher rates of anterior pituitary deficiencies, while patients who underwent CT had higher rates of visual dysfunction. Conversely, QoL was impaired to a similar extent in all patients independent of DI & CT, while higher BMIs in the DI & CT groups imply a role of hypothalamic damage in impacting the morbidity of COCP patients.
Nothing to Disclose: KCJY, DMC, MK, JLF, PJJ, MEG, RA
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
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