UNLIKE IN CAUCASIANS, FGF-21 AND RBP4 DO NOT DIFFER IN CHINESE-AMERICAN WOMEN WITH OR WITHOUT GESTATIONAL DIABETES

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 806-823-Gestational Diabetes
Basic/Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-809
So-Young Kim*1, Vanessa Sy1, Nicole Babushkin1, Doris Tan1, Emilia Pauline Liao2, George Liu3, Stephen Wan1, Leonid Poretsky2 and Donna L T Seto-Young2
1Beth Israel Medical Center, New York, NY, 2Beth Israel Med Ctr, New York, NY, 3United Medical Group, New York, NY
Introduction:  Gestational diabetes (GDM) complicates 3.2 to 5% of the pregnancies, with higher prevalence seen in Asian women. Elevated levels of fibroblast growth factor (FGF)-21, retinol binding protein-4 (RBP4), and resistin and both elevated and decreased levels of IGF-1 have been reported in Caucasians with GDM.  To our knowledge, no similar studies have been carried out in Chinese-American women.

Material and Methods:  We measured the serum levels of IGF-1, IGFBP-1, FGF-21, RBP4 and resistin in 221 Chinese-American women at 24-28 weeks of gestation.  Blood samples were drawn 1-hour after the 50-gm glucose load during the glucose challenge test (1HGCT).  Correlation coefficients for the indicators of glucose tolerance (1HGCT, HbA1c, insulin and BMI) were calculated against the above markers.  

Results: There were no significant differences in the levels of IGF-1, IGFBP-1, leptin, RBP4, resistin or FGF-21 between Chinese-American women with and without GDM. 

Insulin positively correlated with IGF-I (R=0.236, p<0.001) and negatively correlated with IGFBP-1 (R= -0.291, p<0.001).  FGF-21 positively correlated with insulin (R=0.237, p<0.001), BMI (R=0.234, p<0.001), and 1HGCT (R=0.162, p<0.017).  Resistin did not significantly correlate with any of the glucose tolerance markers. The strength of the correlation between BMI and the examined markers ranked as follows: leptin>FGF-21>RBP4>insulin (R=0.402, 0.234, 0.166 and 0.155, respectively).

Conclusion:  In contrast to the reports in Caucasians with GDM, circulating levels of IGF-1, IGFBP-1, FGF-21, leptin, RBP4 or resistin do not differ significantly in Chinese-American women with or without GDM. FGF-21, IGF-I and RBP4 correlate only weakly with indicators of increasing glucose intolerance. The reasons for the differences between our study in Chinese women and studies in Caucasians may have to do with lower BMI and younger age of our patients. Alternately, the role of the markers examined in this report in the development of glucose intolerance during pregnancy in Chinese-American women may differ from their role in Caucasians. Studies with contemporaneous Caucasian control population are needed to address this issue definitively.

Nothing to Disclose: SYK, VS, NB, DT, EPL, GL, SW, LP, DLTS

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm