Session: MON 723-757-Renin-Angiotensin-Aldosterone System/Endocrine Hypertension
Bench to Bedside
Poster Board MON-750
Methods: Data from 1,428 women from the population-based Study of Health in Pomerania were used. Associations of total testosterone (TT), androstenedione, sex hormone-binding globulin (SHBG), and free testosterone concentrations with BP and hypertension were analyzed in multivariable cross-sectional and longitudinal regression models in the full sample and stratified by menopausal status.
Results: A positive association between TT and BP was revealed in the full sample [systolic blood pressure (SBP): β per standard deviation (SD) increase: 3.22; pulse pressure (PP): β per SD increase: 2.30] and among post-menopausal women [diastolic blood pressure (DBP): β per SD increase: 3.33; SBP: β per SD increase: 7.11; PP: β per SD increase: 3.77]. Longitudinal analyses also showed a positive association between baseline TT and follow-up BP. Furthermore, low TT concentrations were associated with a decreased risk of prevalent hypertension in all women [relative risk (RR) quartile 1 (Q1) vs. Q4, 0.79; 95% CI, 0.67 – 0.94]. Low SHBG was associated with prevalent hypertension in post-menopausal women (RR, 1.27; 95%CI, 1.06 – 1.53) and with incident hypertension in the full sample (RR, 1.73; 95%CI, 1.10 – 2.75).
Conclusions: The present population-based study is the first to show a consistent positive association between TT and BP in both, cross-sectional and longitudinal analyses; suggesting high TT as a risk marker of increased BP as well as prevalent hypertension in women.
Nothing to Disclose: BZ, HW, HV, RR, MD, MN, BGK, GB, RH
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