Positive association between testosterone, blood pressure, and hypertension in women

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 723-757-Renin-Angiotensin-Aldosterone System/Endocrine Hypertension
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-750
Benedict Ziemens*1, Henri Wallaschofski2, Henry Völzke3, Rainer Rettig3, Marcus Dörr3, Matthias Nauck3, Brian George Keevil4, Georg Brabant5 and Robin Haring6
1University of Greifswald, Greifswald, Germany, 2Univ of Greifswald, Greifswald, Germany, 3University of Greifswald, 4Univ Hospital of South Mancheste, Manchester, United Kingdom, 5Experimental and Clinical Endocrinology, Luebeck, Germany, 6Ernst-Moritz-Arndt University, Greifswald, Germany
Background:The association between sex hormones and blood pressure (BP) in women has been investigated mostly in cross-sectional studies yielding inconsistent results.

Methods: Data from 1,428 women from the population-based Study of Health in Pomerania were used. Associations of total testosterone (TT), androstenedione, sex hormone-binding globulin (SHBG), and free testosterone concentrations with BP and hypertension were analyzed in multivariable cross-sectional and longitudinal regression models in the full sample and stratified by menopausal status.

Results: A positive association between TT and BP was revealed in the full sample [systolic blood pressure (SBP): β per standard deviation (SD) increase: 3.22; pulse pressure (PP): β per SD increase: 2.30] and among post-menopausal women [diastolic blood pressure (DBP): β per SD increase: 3.33; SBP: β per SD increase: 7.11; PP: β per SD increase: 3.77]. Longitudinal analyses also showed a positive association between baseline TT and follow-up BP. Furthermore, low TT concentrations were associated with a decreased risk of prevalent hypertension in all women [relative risk (RR) quartile 1 (Q1) vs. Q4, 0.79; 95% CI, 0.67 – 0.94]. Low SHBG was associated with prevalent hypertension in post-menopausal women (RR, 1.27; 95%CI, 1.06 – 1.53) and with incident hypertension in the full sample (RR, 1.73; 95%CI, 1.10 – 2.75).

Conclusions: The present population-based study is the first to show a consistent positive association between TT and BP in both, cross-sectional and longitudinal analyses; suggesting high TT as a risk marker of increased BP as well as prevalent hypertension in women.

Nothing to Disclose: BZ, HW, HV, RR, MD, MN, BGK, GB, RH

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