Session: SAT 26-40-Glucocorticoid Actions & Disease
Poster Board SAT-40
Our new study focused on a possible role of 11βHSD and above named NAS in cerebrospinal fluid of patients with hydrocephalus, enabling prediction and consequent targeted treatment of dementia, which, after initial relief, appears in most of the patients. We predict the crucial role of 11β-HSD in the pathogenesis of hydrocephalus.
Similar principle of disturbed levels of 7-hydroxylated DHEA metabolites (produced mainly in glial cells) could be caused by the disturbances in 11β-HSD activity in another very serious disease – multiple sclerosis.
The above mentioned steroids act as regulators of local cortisol activity due to their competition in the cortisol-cortisone balance mediated by 11β-HSD. 7-Hydroxy-dehydroepiandrosterone is marketed as anti-obesity dietary supplement, though no clinical study has appeared until now. The aim of our other most recent project was to contribute to the discovery of new hormonal factors involved in the formation and development of obesity in children.
Currently, we are studying the role 11β-HSD in men with fertility disturbances where enzyme activity could be negatively affected by endocrine disruptors resulting in extensive glucocorticoid activity. The consequence of it is the inhibition of gene expression of LH receptors in Leydig cells and the disorders in testosterone and sperm production. We hope that results of our studies summarized here could lead to a new therapeutic approaches of disorders outlined above.
The works are supported by the grants IGA NT/13369, NT/12349-4, NT 13542-3 from the Czech Ministry of Health.
Nothing to Disclose: MB, LS, JK, LM, RH, LS
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