A PEDIATRIC BONE MASS SCAN HAS LOW ABILITY TO PREDICT ADULT BONE MASS-A 28-YEAR PROSPECTIVE STUDY IN 214 CHILDERN

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 224-247-Osteoporosis I
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-243
Magnus Karlsson*1, Björn Rosengren1, Magnus Tveit2, Lennart Landin1, Jan-Åke Nilsson3 and CHristian Buttazzoni4
1Inst of Clinical Sciences, Malmö, Sweden, 2Inst of Clinical Sciecnes, Malmö, Sweden, 3Inst of Clinical Scienses, Malmö, Sweden, 4Inst of Clinical Scicens, Malmö, Sweden
Purpose: It is currently unclear to what extent bone mass tracks from growth to adulthood. We therefore conducted a long-term prospective observational study to determine the usefulness of a bone mass scan in childhood in predicting adult bone mass.

Methods: We measured cortical bone mineral content (BMC; g), bone mineral density (BMD; g/cm2) and bone width (cm) in the distal forearm by single photon absorptiometry in 120 boys and 94 girls with a mean age of 10 years (range 3–17) and mean 28 years (range 25–29) later. Individual bone mass Z-scores were calculated, with all attenders at each measurement as reference. Pearson’s correlation coefficient was used to evaluate correlations between the two measurements. Individual Z-scores were also stratified into quartiles to evaluate movement between quartiles from growth to adulthood.

Results: BMD in childhood and adulthood correlated in both boys (r=0.35; p<0.0001) and girls (r=0.50, p<0.0001). The same was found in children ≥10 years at baseline (boys r=0.43 and girls r=0.58, both p<0.0001) and in children <10 years at baseline (boys r=0.26 and girls r=0.40, both p<0.05). Of the children in the lowest quartile of BMD, 58% had left the lowest quartile in adulthood. A BMD value in the lowest quartile had a sensitivity of 48% (95% CI 27%, 69%) and a specificity of 76% (95% CI 66%, 84%) to identify individuals who would remain in the lowest quartile also in adulthood.

Conclusions: Childhood BMD explained 12% of the variance in adult BMD in men and 25% in women. A pediatric distal forearm BMD scan has poor ability to predict adult bone mass

Nothing to Disclose: MK, BR, MT, LL, JN, CB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm