Session: SAT 224-247-Osteoporosis I
Poster Board SAT-243
Methods: We measured cortical bone mineral content (BMC; g), bone mineral density (BMD; g/cm2) and bone width (cm) in the distal forearm by single photon absorptiometry in 120 boys and 94 girls with a mean age of 10 years (range 3–17) and mean 28 years (range 25–29) later. Individual bone mass Z-scores were calculated, with all attenders at each measurement as reference. Pearson’s correlation coefficient was used to evaluate correlations between the two measurements. Individual Z-scores were also stratified into quartiles to evaluate movement between quartiles from growth to adulthood.
Results: BMD in childhood and adulthood correlated in both boys (r=0.35; p<0.0001) and girls (r=0.50, p<0.0001). The same was found in children ≥10 years at baseline (boys r=0.43 and girls r=0.58, both p<0.0001) and in children <10 years at baseline (boys r=0.26 and girls r=0.40, both p<0.05). Of the children in the lowest quartile of BMD, 58% had left the lowest quartile in adulthood. A BMD value in the lowest quartile had a sensitivity of 48% (95% CI 27%, 69%) and a specificity of 76% (95% CI 66%, 84%) to identify individuals who would remain in the lowest quartile also in adulthood.
Conclusions: Childhood BMD explained 12% of the variance in adult BMD in men and 25% in women. A pediatric distal forearm BMD scan has poor ability to predict adult bone mass
Nothing to Disclose: MK, BR, MT, LL, JN, CB
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