FP10-1 Elevated Serum Dickopff-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: FP10-Osteoporosis & Other Metabolic Bone Diseases
Bench to Bedside
Saturday, June 15, 2013: 11:00 AM-11:30 AM
Presentation Start Time: 11:00 AM
Room 121 (Moscone Center)

Poster Board SAT-224
Aarthi Arasu*1, Peggy M Cawthon2, Li-Yung Lui2, Jane A Cauley3, Kristine E Ensrud4 and Steven R Cummings5
1UCLA, Torrance, CA, 2California Pacific Medical Center, San Francisco, CA, 3University of Pittsburgh, Pittsburgh, PA, 4University of Minnesota, Minneapolis, MN, 5CA Pacific Med Ctr, San Francisco, CA
Context: Dickopff-1 (DKK-1), an osteocyte-secreted inhibitor of the Wnt pathway, decreases bone formation. We have shown that sclerostin, another Wnt antagonist, increased risk of hip fracture in older women independent of bone mineral density.

Objective: To test the hypothesis that elevated serum DKK-1 levels are associated with increased risk of hip and vertebral fractures in older women.

Design, Setting, and Participants: SOF prospectively studied a community based cohort of 9704 women aged ≥65 years.  DKK-1 levels were measured by the Biomedica ELISA assay in serum collected in 1989-90 in 228 women with subsequent hip fractures, 109 women with new vertebral fractures, and 227 women randomly selected from the cohort. Average follow-up time was approximately 9.8 years for hip fractures and 3.5 years for vertebral fractures.  

Results: The risk of hip fracture increased across quartiles of serum DKK-1 (test for trend, p<0.01).  Women in the highest quartile of DKK-1 (43.2-174.9 pmol/L) had about twice the risk of hip fracture (HR 2.2, 95% CI 1.2-3.8) compared to women in the lowest quartile (4.8 – 21.5 pmol/L).  The risk of vertebral fracture increased by 39% for every 1 standard deviation (22.6 pmol/L) increase in DKK-1 levels (OR 1.39, 95% CI 1.09-1.78).  Results were similar after adjusting for age, body mass index, estrogen use, history of fracture since age 50, and BMD for both hip and vertebral fractures.  Serum DKK-1 levels did not significantly correlate with total hip bone mineral density

Conclusions: We conclude that higher serum DKK1 levels are associated with a greater risk of hip and vertebral fractures in older women. 


Nothing to Disclose: AA, PMC, LYL, JAC, KEE, SRC

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Biomedica
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