Session: FP10-Osteoporosis & Other Metabolic Bone Diseases
Bench to Bedside
Room 121 (Moscone Center)
Poster Board SAT-224
Objective: To test the hypothesis that elevated serum DKK-1 levels are associated with increased risk of hip and vertebral fractures in older women.
Design, Setting, and Participants: SOF prospectively studied a community based cohort of 9704 women aged ≥65 years. DKK-1 levels were measured by the Biomedica ELISA assay in serum collected in 1989-90 in 228 women with subsequent hip fractures, 109 women with new vertebral fractures, and 227 women randomly selected from the cohort. Average follow-up time was approximately 9.8 years for hip fractures and 3.5 years for vertebral fractures.
Results: The risk of hip fracture increased across quartiles of serum DKK-1 (test for trend, p<0.01). Women in the highest quartile of DKK-1 (43.2-174.9 pmol/L) had about twice the risk of hip fracture (HR 2.2, 95% CI 1.2-3.8) compared to women in the lowest quartile (4.8 – 21.5 pmol/L). The risk of vertebral fracture increased by 39% for every 1 standard deviation (22.6 pmol/L) increase in DKK-1 levels (OR 1.39, 95% CI 1.09-1.78). Results were similar after adjusting for age, body mass index, estrogen use, history of fracture since age 50, and BMD for both hip and vertebral fractures. Serum DKK-1 levels did not significantly correlate with total hip bone mineral density
Conclusions: We conclude that higher serum DKK1 levels are associated with a greater risk of hip and vertebral fractures in older women.
Nothing to Disclose: AA, PMC, LYL, JAC, KEE, SRC
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