Session: OR22-Male Reproductive Hormones: Effects on Fertility and Beyond
Room 104 (Moscone Center)
Objective and Main Outcome Measures: We determined, before and after high and low fat diet modulation, changes in the conversion of T to 5α- and 5β-diols and androgen levels in prostatic tissues obtained at biopsy in men with elevated PSA but without evidence of PCa on first biopsy.
Design, Setting, Participants and Methods: 56 men (mean age 60±1 years) with elevated serum PSA but without PCa on initial biopsy who were usually taking a high fat diet participated in the study. 30 subjects were randomized to take a diet mimicking their home diet (>30% calories as fat) and 26 to a diet containing 10 to 15% of total calories from fat and 25 to 35 g fiber/day for 8 weeks. Clinically indicated prostate biopsies were performed before and after diet modulation because of a persistent elevated PSA. Conversion of T to the 5α- and 5β-reduced metabolites and prostate androgens were measured by GC-MS using established methods.
Results: Conversion of T to DHT and 5α,3α-diol were increased from baseline after both high and low fat diet groups without between group differences. Conversion of T to 5α,3β-diol (p=0.04) and the 5β,3α-diols (p=0.04) were only increased with low fat diet. Serum androgens were very low or non-detectable in many biopsies, but prostatic 5β,3α-diol levels decreased after high fat diet but increased with low fat diet and the difference between the two groups were significant (p=0.01).
Conclusions: Conversion of T to DHT and 5α, 3α-diol was increased with both diets. Low fat diet significantly induced conversion of T to less active 5α,3β- and 5β, 3α-diols metabolites. This suggests diet modulation may affect androgen metabolism to form less active metabolites in the prostate.
Abbreviations: T=testosterone, DHT = 5α dihydrotestosterone, 5α,3α-diol= 5α,3α-androstanediol, 5α,3β-diol= 5α,3β-androstanediol, 5β,3α-diol= 5β,3α-androstanediol, and 5β,3β-diol= 5β3β-androstanediol. GC-MS= gas chromatography-mass spectrometry.
Disclosure: JR: Investigator, Allergen. Nothing to Disclose: CCW, HV, PJN, AL, TV, RB, PC, LH, RS, SF, LB, RSS
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