Decreasing 25-hydroxy vitamin D3 levels are associated with high prevalence of Hashimoto thyroiditis in pre- and post- menopausal women

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 432-458-Thyroid Autoimmunity
Basic/Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-445
Yun Mi Choi*, Tae Yong Kim, Eun Kyung Jang, MinJi Jeon, Ji Min Han, Sung Jin Bae, Hong-Kyu Kim, Jung-Min Koh, Ghi Su Kim, YoungKee Shong and Won Bae Kim
Asan Med Ctr, Seoul, South Korea
Backgrounds: Vitamin D deficiency has been reported to be prevalent in several autoimmune diseases including Hashimoto thyroiditis (HT). Aim of this study was to compare the prevalence of HT according to serum 25-hydroxy vitamin D3 (25(OH)D3) levels among subjects who underwent routine health check-up.

Subjects and Methods: A population who had undergone comprehensive routine health examinations between 2008 and 2012 was considered for analysis in this study. The serum 25(OH)D3 levels and serum anti TPO Ab levels were measured, and thyroid ultrasonographies were also performed. Diagnosis of HT was defined as positive TPO Ab and patterns of ultrasonography suggesting diffuse parenchymal disease of thyroid.

Results: Seven thousand two hundred eighteen subjects were included in this study (3,953 men and   3,265 women). Median age was 54 years old (range 35 to 75). Overall prevalence of HT was 5.5% (2.3%, men; 9.4%, women). Subjects were classified into deficient (n=420, 5.8%), insufficient (n=4.517, 62.6%), and sufficient group (n=2,281, 31.6%) according to 25(OH)D3 level; less than 10 ng/mL, between 10 and 30 ng/mL, and more than 30 ng/mL, respectively.

The prevalence of HT was not significantly different in men according to 25(OH)D3 status (p= 0.371). However, in women, there was significant difference in HT prevalence; 15%, 10%, and 7% in deficient, insufficient, and sufficient group, respectively (p < 0.001). We subcategorize women into pre-menopause (n=970) and post-menopause (n=2295). The prevalence of HT was still significantly different according to vitamin D status group regardless of menopausal status (pre-menopause, 17%, 10%, and 4% in deficient, insufficient, and sufficient group, respectively, p < 0.001; post-menopause, 14%, 10%, and 8% % in deficient, insufficient, and sufficient group, respectively,  p = 0.03)

Conclusion: Vitamin D may have a potential role in developing HT in women. Thus, further study regarding vitamin D supplements for preventing HT could be warranted.

Nothing to Disclose: YMC, TYK, EKJ, MJ, JMH, SJB, HKK, JMK, GSK, YS, WBK

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm