Session: MON 758-775-Beta Cells, Glucose Control & Complications
Poster Board MON-759
Methods:Patients undergoing pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) were recruited. The β-cell function and PVs were evaluated before and after pancreatectomy. Fasting C-peptide levels (F-CPR), stimulated C-peptide values (6min-CPR) and ΔCPR with glucagon stimulation test were used to assess β-cell function. ΔCPR was calculated on the basis of the formula ΔCPR = 6min-CPR minus F-CPR. The PVs were measured with 64-row multidetector computed tomography.
Results: A total of 47 patients (mean age 71±10 years; 18 female and 29 male; 29 patients with PD and 18 patients with DP) were enrolled. Median values of C-peptide levels with glucagon test and PV were significantly decreased after pancreatectomy (pre-operative vs. post-operative, P value. F-CPR: 1.8 vs. 1.4 ng/ml, P<0.001, 6min-CPR: 4.1 vs. 2.7 ng/ml, P<0.001, ΔCPR: 2.3 vs. 1.3 ng/ml, P<0.001 and PV: 48.1 vs. 19.1 cm3, P<0.001, respectively). Postoperative C-peptide levels were significantly correlated with postoperative PVs (post F-CPR: r=0.509, P<0.001, post 6min-CPR: r=0.641, P<0.001 and post ΔCPR: r=0.703, P<0.001, respectively). There were also significant correlations between postoperative C-peptide levels and postoperative PV according to pancreatectomy (PD; post F-CPR: r=0.444, P=0.018, post 6min-CPR: r=0.554, P=0.002 and post ΔCPR: r=0.612, P=0.001, respectively. DP; post F-CPR: r=0.542, P=0.020, post 6min-CPR: r=0.684, P=0.002 and post ΔCPR: r=0.751, P<0.001, respectively). Additionally, median value of postoperative C-peptide with glucagon stimulation test to postoperative PV ratios was not significantly different between patients with PD and DP.
Conclusions: Irrespective of resection portion, pancreatic endocrine function decreased with a PV. Postoperative pancreatic endocrine function depended on remaining PV.
Nothing to Disclose: TS, MY, TA, TS, KU, YM, SN
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