Evaluation of fasting and postprandial plasma GLP-1 concentrations in childhood obesity

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 649-675-Central Regulation of Appetite & Feeding/GI Regulatory Peptides
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-655
Meltem Tayfun*1, Orhun Çamurdan2, Aysun Bideci3 and Peyami Cinaz3
1T.C. S.B. Ankara Çocuk Sagligi ve Hastaliklari Hematoloji Onkoloji Egitim ve Arastirma Hastanesi, Ankara, Turkey, 2Gazi Üniversitesi Tip Fakültesi Cocuk Sagligi ABD, Ankara, Turkey, 3Gazi Üniversitesi Tip fakültesi Pediyatri ABD, Ankara, Turkey
Objective and Hypotheses: The prevalence of obesity is increasing  and intestinal endocrine system is noteworthy because of the role of regulators of appetite. This study was designed to find out whether there is any difference in the  concentrations fasting and postprandial plasma glucagon like peptid-1  (GLP-1) in obesity and normal weight children.

Material and Method: The study population consisted of 40 obese and 15 healthy control children. Children ages ranged from 11.2 to 17.6 years old.  Groups are consisted: patients who are obese and insulin resistance (n=20, Group I) and obese without insulin resistance  (n=20, Group II)  and  nonobese healthy control group (Group III). In obese patients, 23 (57.5%) were female and 17 (42.5%) men and  in the control group, 6 (40%) were female and 9 (60%) were male. whose age, sex, height, weight, BMI, and pubertal  status are matched. Immediately after sampling for fasting blood glucose, insulin and GLP-1 levels. The  subjects were administered a standard oral glucose tolerance test. Another sampling was performed for plasma glucose,insülin and  GLP-1 levels at 60-120 minutes.

Results: Plasma GLP-1 levels both pre and 60,120 min  after OGTT; were different between groups. 60th and 120th min GLP-1 levels were significantly decreased in Group I compared to  Group II and III.  Plasma GLP-1 levels both 60,120 min after OGTT; were statistically significant  between Groups I-II and Groups I-III (p<0.05).There were not  GLP-1 level difference between groups II and III. Serum GLP-1 showed no significant correlations between antropometric data, glucose,insülin,lipid profile and HOMA-IR in the obese groups.

Conclusions:  The  concentrations fasting and postprandial plasma GLP-1 reduced  in obesity  with insulin resistance after  an oral glucose load.  This decreased levels of GLP-1 study  results in, as a suggesting role for GLP-1 in the obesity pathogenesis and  in the future. GLP-1 treatment of children with  obesity and type 2 diabetes may give  hope to patients.

Nothing to Disclose: MT, O, AB, PC

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm