Session: MON 649-675-Central Regulation of Appetite & Feeding/GI Regulatory Peptides
Bench to Bedside
Poster Board MON-655
Material and Method: The study population consisted of 40 obese and 15 healthy control children. Children ages ranged from 11.2 to 17.6 years old. Groups are consisted: patients who are obese and insulin resistance (n=20, Group I) and obese without insulin resistance (n=20, Group II) and nonobese healthy control group (Group III). In obese patients, 23 (57.5%) were female and 17 (42.5%) men and in the control group, 6 (40%) were female and 9 (60%) were male. whose age, sex, height, weight, BMI, and pubertal status are matched. Immediately after sampling for fasting blood glucose, insulin and GLP-1 levels. The subjects were administered a standard oral glucose tolerance test. Another sampling was performed for plasma glucose,insülin and GLP-1 levels at 60-120 minutes.
Results: Plasma GLP-1 levels both pre and 60,120 min after OGTT; were different between groups. 60th and 120th min GLP-1 levels were significantly decreased in Group I compared to Group II and III. Plasma GLP-1 levels both 60,120 min after OGTT; were statistically significant between Groups I-II and Groups I-III (p<0.05).There were not GLP-1 level difference between groups II and III. Serum GLP-1 showed no significant correlations between antropometric data, glucose,insülin,lipid profile and HOMA-IR in the obese groups.
Conclusions: The concentrations fasting and postprandial plasma GLP-1 reduced in obesity with insulin resistance after an oral glucose load. This decreased levels of GLP-1 study results in, as a suggesting role for GLP-1 in the obesity pathogenesis and in the future. GLP-1 treatment of children with obesity and type 2 diabetes may give hope to patients.
Nothing to Disclose: MT, O, AB, PC
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