HbA1c reflects Framingham Risk Score in Korean Nondiabetic Middle-Aged General Population

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 776-795-Cardiometabolic Risk & Vascular Biology
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-778
Sang Yong Kim*, Hak Yeon Bae, Jin Hwa Kim, Ji Hye Shin, Jung Hae So and Ji In Kang
Chosun University Hospital, Gwangju, South Korea
Background: HbA1c level has been suggested to be associated with cardiovascular disease (CVD) risk even among people without diabetes. The Framingham risk score (FRS) is a wide used model for predicting CVD during a 10 year period. Our objective was to evaluate the relationship between HbA1c level and CVD risk by FRS in Korean nondiabetic middle-aged apparently healthy adults. 

Methods: We retrospectively studied 2,879 Korean adults who were 40-79 years of age or older and underwent voluntary regular health check-ups at the Health Promotion Center of our hospital from July 2009 to June 2011. The subjects were subdivided into four groups, following the tertile groups on the HbA1c normal tolerance range and an increased risk for diabetes (IRD) group according to the HbA1c level. The division by tertile within the normal tolerance range was as follows: lower tertile (LT), HbA1c ≤ 5.3%; middle tertile (MT), 5.3 % < HbA1c ≤ 5.5%; and upper tertile (UT), 5.5 % < HbA1c < 5.7%.

 Results: The mean FRS was 9.4 ± 4.0, and the mean 10 year CVD risk was 4.4 ± 5.1%. FRS in the UT (9.6 ± 3.8) was significantly higher compared with the MT (8.4 ± 4.0) and LT (7.6 ± 3.8) groups. Moreover, FRS was highest in IRD (10.5 ± 3.7). 10 year CVD risk in the UT (4.9 ± 4.9%) and IRD (5.2 ± 5.7%) was also significantly higher compared with the MT (3.3 ± 4.3%) and LT (3.2 ± 4.2%) groups. A multiple linear regression analysis indicated that HbA1c level had a significant positive correlation with FRS when confounding variables were adjusted for total (β ± SE, 0.018 ± 0.002, R2, 0.131), women (0.023 ± 0.003, 0.170), and men (0.016 ± 0.004, 0.109). 

Conclusion: HbA1c level was positively correlated with FRS in Korean nondiabetic middle-aged apparently healthy adults. We propose that HbA1c may reflect CVD risk that is associated with nondiabetic hyperglycemia in people without diabetes.

Nothing to Disclose: SYK, HYB, JHK, JHS, JHS, JIK

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm