NON-ALCOHOLIC FATTY LIVER DISEASE IS NOT ASSOCIATED WITH VITAMIN D DEFICIENCY IN ESSENTIAL HYPERTENSION

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Basic/Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-271
Cristiana Catena1, Valentina Camozzi2, Chiara Cosma2, Mario Plebani2, Mario Ermani2, Leonardo A Sechi1 and Francesco Fallo*2
1University of Udine, Udine, Italy, 2University of Padova, Padova, Italy
An independent association between non-alcoholic fatty liver disease (NAFLD), a condition characterized by insulin-resistance, and low serum 25-hydroxyvitamin D [25(OH)D] levels has been reported. 25(OH)D concentrations are directly related with insulin sensitivity, whereas low [25(OH)D] predicts development of hypertension independent of alterations in glucose homeostasis.  We hypothesized that hypertensive patients with NAFLD have lower 25(OH)D than those without. We investigated in a group of essential hypertensive (EH) patients without additional cardio-metabolic risk factors the relationships between 25(OH)D levels, metabolic parameters and NAFLD. Forty-four never treated hypertensive patients (20 males/24 females, mean age 47±11 yrs.) with grade 1-2 essential hypertension were selected as having (n=23) or not having (n=21) NAFLD at ultrasonography. No patient had diabetes mellitus, obesity, hyperlipidemia, or other risk factors for liver disease. Twenty-four healthy normotensive sex-, age-, BMI-matched subjects served as controls for estimation of both NAFLD and hypovitaminosis D prevalence. The two patient subgroups were similar as to age, sex, and blood pressure levels. Body mass index, waist circumference, glucose, insulin, HOMA index and AST were higher (from P <0.001 to <0.05) and adiponectin was lower (P <0.05) in patients with NAFLD than in patients without NAFLD. Prevalence of NAFLD was higher in EH patients than in controls (23/44, i.e. 52.2%, vs. 4/24, i.e.16.6%, P<0.001), whereas vitamin D deficiency, as defined by 25(OH)D levels <50 nmol/L, was similarly frequent in EH patients and controls (47.7%  vs. 45.8%, P NS).  Prevalence of hypovitaminosis D was not different in EH patients with and without NAFLD (37.5% vs. 38.8%, P NS). No difference in serum calcium, phosphate, 25(OH)D, 1,25(OH)D and PTH levels was observed in EH patients and controls, with or without NAFLD. Conclusion: In a population of EH patients without additional cardio-metabolic risk factors, NAFLD is associated with insulin resistance but not with vitamin D deficiency.

Nothing to Disclose: CC, VC, CC, MP, ME, LAS, FF

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