Session: MON 471-496-Thyroid Neoplasia & Case Reports
Poster Board MON-485
Method: We recruited 18 females with structurally and biochemically normal thyroids proven by ultrasound and TSH and Free T4 (CG). We used the Thyroid Tumor Cancer Collaborative Register (TCCR) at the University of Nebraska Medical Center for the age, gender, and BMI matched papillary thyroid carcinoma (PTCG n = 36) and benign thyroid nodules (BNG n = 18) participants. We analyzed leptin utilizing an ELISA Leptin kit. The correlation between leptin and BMI, TSH, free T4, and age were examined using a Spearman’s correlation coefficient. Correlation of PTCG with TNM scores, stage, active, and inactive disease was evaluated using the Kruskal-Wallis test.
Results: Leptin levels were not significantly different between groups; however, there was a trend for higher leptin levels in the PTCG cohort (p = 0.0730; CG [10 to 23.3 ng/ml]; BNG [8.2 to 22.2 ng/ml]; PTCG [13.5 to 46.55 ng/ml]). Interestingly, leptin between CG and BNG was nearly identical (10 to 23.3 and 8.2 to 22.2 ng/ml respectively). As expected, leptin was significantly correlated with both BMI (p = <.0001) and age (p = 0.0006).
Conclusions: Although differences in leptin levels were not statistically significant between groups, a clear trend towards higher leptin levels was seen in PTCG compared to both CG and BNG. The levels between BNG and CG were similar. This warrants a larger prospective trial to ascertain if Leptin can be used clinically as a biomarker to help stratify benign nodules from malignant nodules.
Nothing to Disclose: OMZA, WSG
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