Session: MON 842-862-Insulin Signaling & Action
Poster Board MON-851
Research Design and Methods – In paired samples of omental and subcutaneous (SC) AT from 256 lean and obese participants, we investigated whether Fas mRNA expression is fat depot-specific, altered in obesity and related to measures of AT inflammation and insulin sensitivity.
Results – Fas is significantly higher expressed in omental compared to SC AT. Fas expression correlates with BMI (OM, r²=0.44, SC, r²=0.14), AT macrophage infiltration (OM, r²=0.36, SC, r²=0.16) and glucose infusion rate in euglycemic-hyperinsulinemic clamps (OM, r²=0.17, SC, r²=0.13) (p<0.05 for all). Insulin sensitive had significantly lower Fas expression than insulin resistant obese individuals.
Conclusions –Independently of body weight, increased Fas expression may contribute to impaired insulin sensitivity and AT dysfunction in obesity.
Nothing to Disclose: MB, NK, SW, EJS, MRS, AD, MF, MS, DK
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