FP18-4 The Effects of ‘Catch-Up' Sleep On Insulin Sensitivity in Men With Lifestyle Driven, Chronic, Intermittent Sleep Restriction

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: FP18-Diabetes: Glycemia & Insulin Sensitivity
Basic/Clinical
Sunday, June 16, 2013: 10:45 AM-11:15 AM
Presentation Start Time: 11:00 AM
Room 304 (Moscone Center)

Poster Board SUN-782
Roo Killick1, Camilla M Hoyos1, Kerri Melehan1, George C Dungan II1, Jonathon Poh1 and Peter Y Liu*2
1NHMRC Centre for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia, 2Los Angeles Biomedical Research, Torrance, CA
Introduction: Chronic, intermittent sleep restriction is increasingly common in modern society. Previous data have shown significant effects of experimental sleep restriction on insulin sensitivity and metabolic outcomes in healthy, normal sleepers. To our knowledge, this has not been studied before in men with chronic, intermittent, lifestyle-driven sleep restriction: the population of interest.

Methods: 19 men (mean±SEM age 28.6±2.0years, BMI 26.0±0.8kg/m2) with at least 6 months’ history (5.1±0.9years) of lifestyle driven, restricted sleep during the working week (373±6.6 min/night)  with regular weekend ‘catch up’ sleep (weekend sleep extension 37.4±2.3%) completed an in-laboratory, randomised, cross-over study comprising 2 of 3 conditions, stratified by age. Conditions were 3 weekend nights of either: 10 hours, 6 hours or 10 hours time-in-bed with slow wave sleep suppression using acoustic stimuli. Reported sleep was verified at screening and before each laboratory visit by two weeks of actigraphy. Insulin sensitivity was measured on the fourth morning by minimal modelling from 19 samples drawn during a 2 hour oral glucose tolerance test. Daily fasting blood samples were taken for glucose, insulin, c-peptide; HOMA-IR, HOMA-B and QUICKI were calculated. Food intake was identical for each individual during each study visit.

Results: Insulin sensitivity improved (mean difference 8.57 x 104 min-1 (µU/ml)-1, 95% CI 1.1 to 16.1 x104, p=0.03) following 3 nights of sleep extension compared to persisting sleep restriction. Fasting insulin (-1.37iu/ml, -2.4 to -0.3, p=0.01), c-peptide (-95.8pmol/L, -144.8 to -46.8, p=0.0003), HOMA-IR (-0.31,-0.56 to -0.05, p=0.02) and HOMA-B (-18.6, -29.5 to -7.6, p=0.002) decreased, while QUICKI (0.01, 0.003 to 0.02, p=0.01) increased with sleep extension. Slow wave sleep suppression reduced SWS quantity by 23% (- 12.6min, -23.4 to -1.8, p=0.02), predominantly on night 1, and NREM delta power by power spectral analysis by 10% (-41.7 µV2, -69.3 to -13.9, p=0.005), without altering total sleep time or fragmentation, but this did not alter insulin sensitivity in this sleep deprived cohort.

Conclusion: In men with chronic, intermittent sleep restriction, 3 nights of ‘catch-up’ sleep improved insulin sensitivity. Sleep extension could prevent development of insulin resistance and diabetes mellitus.

Nothing to Disclose: RK, CMH, KM, GCD II, JP, PYL

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm