DIABETES RISK SCORE, COFFEE INTAKE AND SLEEP DURATION IN DIABETICS WITH AND WITHOUT CANCER: THE ROLE OF FAMILY HISTORY OF DIABETES

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 818-841-Diabetes Pathophysiology & Complications
Basic/Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-838
Lev M Berstein* and Dmitry Vasilyev
N.N.Petrov Research Institute of Oncology, St.Petersburg, Russia
Objectives: Reduced sleep duration is considered to be a risk factor in the current epidemic of several metabolic disorders including obesity and glucose intolerance. Coffee intake is on the contrary assumed to be among external factors preventing diabetes type 2 (DM) due to is relation to estrogen transport and metabolism. Both sleep duration and coffee intake are not included into DM risk assessment (DRA) form, which takes into consideration age, BMI, waist circumference, physical activity, eating of vegetables, fruits and berries, use of antihypertensive medications, blood glucose increase, and occurrence of relatives with DM. Diabetics with and without cancer were not compared earlier in regard of the mentioned factors and one of the aims of this pilot study was to fill this gap. Materials and methods: Totally 184 postmenopausal females in age 48-84 were included. The group consisted of 76 patients with recently discovered DM and cancer, 44 diabetics without cancer, 20 not treated cancer patients without diabetes and 44 healthy women; there were respectively 31, 16, 6 and 9 individuals (in toto 62, or 33,7%) with family history (FH) of diabetes. The information on average sleep duration (hrs) and coffee consumption (cups) during last week was collected. Used version of DRA form was developed by Finish Diabetes Association (www.diabetes.fi). Results: DRA value was 17.3±0.43 in DM+cancer group, 14.2±0.87 in diabetics without cancer (p <0.01), 10.4±1.17 in cancer patients without DM, and 8.6±0.9 in healthy females. Increase of DRA score in DM+cancer group vs diabetics without cancer was associated rather with higher BMI and waist circumference than with FH of diabetes. Sleep duration when presented in the above order was 7.26±0.17; 6.43±0.34 (p 0.04); 7.84±0.25; 7.86±0.59 hrs, while coffee intake - respectively 0.97±0.11; 1.00±0.29; 1.23±0.34; and 1.50±0.42 cups (DM vs non-DM respectively 0.98±0.17 and 1.33±0.34). Family history of DM did not influence sleep duration but has been associated with tendency to higher coffee consumption in DM+cancer group. Conclusions: 1. Diabetics are inclined to somewhat lesser coffee drinking than non-diabetics even in the geographical area with not large intake of this beverage. 2. Duration of sleep in diabetics (especially, not having cancer) is shorter than in non-diabetics. 3. Excessive body weight and coffee consumption may differently modify the input of family history of DM into the value of diabetes risk score in postmenopausal females with combination of diabetes and cancer.

Nothing to Disclose: LMB, DV

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Acknowledgements: To Russian Foundation of Basic Research grant 12-04-00084a.