Recurrent Thymic Carcinoid Tumor in Familial Isolated primary Hyperparathyroidism

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 306-326-Neoplasia of Endocrine Tissues: Case Reports
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-326
Eon Ju Jeon*, Mu Hyun Son, Jeong Eun Song, Ji Hyun Lee, Ho Sang Shon and Eui Dal Jung
Catholic University of Daegu School of Medicine, South Korea
Familial isolated hyperparathyroidism (FIHP) is associated with multiple endocrine neoplasia(MEN) 1 sydrome, primary hyperpathyroidism with jaw-tumor syndrome, and familial hypocalciuric hypercalcemia. FIHP may be an early stage of MEN 1 or an allelic variant of MEN 1. Thymic carcinoid tumor is rare in MEN 1 syndrome. Here, we report a case of 40-year-old man who was diagnosed with recurrent thymic carcinoid tumor in FIHP with novel gene mutation. He and his sister were diagnosed with FIHP with novel frameshift mutation in the MEN 1 gene(exon 10). 4-years ago, he underwent thymectomy because of the incidental mediastinal mass found on his chest X-ray. Pancreas computed tomography for MEN 1 syndrome evaluation showed anterior mediastinal mass. He underwent resection for it. Pathologic findings were consistent with atypical carcinoid with infiltrative margin. We recommend periodic surveillance for occult and recurrent tumors.

Nothing to Disclose: EJJ, MHS, JES, JHL, HSS, EDJ

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