Session: MON 471-496-Thyroid Neoplasia & Case Reports
Poster Board MON-477
MATERIALS AND METHODS: Our sample is formed by 109 patients (average age 53,7±13,4, range 18-85 years old, 79,8% women, 27,5% smokers, 18,3% with autoimmune thyroid disease). We have done a FNAB (sonographyc guided) of the thyroid nodules not suspicious of having MTC (average size 20,1± 9,3mm) to all of the patients. The same needle and syringe used in the FNAB was washed with 1ml of a 0.9% sodium chloride solution and was sent to the laboratory in order to measure the calcitonin level in the wash-out fluid. Calcitonin levels in serum (S-CT) and calcitonin levels in wash-out fluid (WO-CT) were measured with a chemiluminescence test (IMMULITE 2000).
RESULTS: In our patients, the average result of S-CT were 3,07+/-3.22 ng/l (range 2-19,4 ng/l), and 3,98+/-10,36 ng/l (range 2-97 ng/l) for WO-CT. In 2 cases, the WO-CT values were 10 times higher than the highest level found. One of the cases presented a cytology compatible with a benign thyroid disease and the other case was compatible with papillary thyroid carcinoma. Both cases were taken to surgery, where a MCT (S-CT/WO-CT: 382/32.250 ng/ml) and a microMTC/hyperplasia cells C (CTs/CT-FNAB: 4,5/1.150 ng/ml) were found respectively. In all other cases, the WO-CT showed no significant correlation with the studied parameters (age, gender/sex, presence of autoimmune thyroiditis, tobacco, BMI), except for a weak correlation with S-CT (r: 0,17, p<0.04).
CONCLUSIONS: Calcitonin measurement in wash-out fluid from FNAB can be an additional and early warning method for a MTC diagnosis.
Nothing to Disclose: TMH, CGG, NGR, PS, AB, ATC, VMM, ASP
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