Session: SAT 292-325-Breast & Prostate Cancer
Poster Board SAT-299
We studied cases from three different Japanese hospitals (DCIS: St Lukes Hospital Tokyo, Tohoku Kosai Hospital Sendai, pIDC/rIDC: Kumamoto City Hospital, Kyushu) with appropriate IRB approval. Immunoreactivity was quantified using H score for nuclear staining (AR) and a semi-quantative score for cytoplasmic staining (5αR1, 17βHSD5) with 10% IR(nuclear) and >50% IR (cytoplasmic) being used to dichotomise the results.
AR LIs were significantly higher in DCIS compared to those in historical IDC cases (AR H Score; DCIS:182, IDC:23, p<0.001). Levels of AR and enzymes demonstrated concordance in 49% of DCIS cases which was correlated well with the 48% concordance reported in our historical IDC data. These findings suggest TNBC DCIS lesions had higher levels of AR but similar levels of concordance between the enzymes and AR to TNBC IDC samples.
In recurrent disease, the status of AR LI between pIDC and rIDC were significantly correlated (p<0.001 RSq=0.79), but not significantly different from that in historical IDC cases. No significant correlations were detected between AR and the enzyme status in these cases.
These results suggest that the loss of AR may be a non obligate step in the progression of triple negative breast cancer but AR remains in a significant proportion of invasive disease. These finding also indicated that a) androgenic pathways were associated with a less invasive TNBC and b) androgen based therapy may not only be effective against primary TNBC but also may have a therapeutic potential in recurrent disease.
Nothing to Disclose: KMM, AMN, TY, YM, NC, EA, YY, HY, KS, HH, RN, NA, TS, MM, KT, TI, NO, HS
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