Serum Uric Acid and the Prevalence of Type 2 Diabetes in Korean Women in Cohort Study

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 758-775-Beta Cells, Glucose Control & Complications
Basic/Translational
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-768
Hochan Cho*1, Gyeongim Yu2, Hyuntae Kim3, Inwook Song3, Byungyeol Chun4 and Donghoon Shin2
1Dongsan Medical Center, Daegu, South Korea, 2Keimyung University School of Medicine, 3Keimyung University DongSan Medical Center, 4Kyungpook National University
The incidence of diabetes is increasing worldwide rapidly and current studies report a direct association between serum uric acid (SUA) and diabetes. Hyperuricemia is known to be associated with gout, hypertension, metabolic syndrome, renal, and cardiovascular diseases. The aim of our study was to investigate the relationship between SUA and type 2 diabetes in ethnic Korean in cohort study.   

We recruited 544 Korean subjects from March 2012 to December 2012. Clinical characteristics, biochemical markers, glucose metabolism status with fasting blood glucose(FBG), 75-g oral glucose tolerance test, and HbA1c were obtained in each subject.

Among 544 subjects (213 males, 357 females), prevalence of diabetes, pre-diabetes, normoglycemic control were 87 (16.0%), 165 (30.3%), and 292 (53.7%) cases according to the diagnostic guideline of Korean diabetes association. Univariate analysis showed that SUA levels, BUN, waist circumference(WC), body mass index(BMI), triglyceride(TG), FBG, and HbA1C were significantly higher in women with type 2 diabetes and WC, BMI, TG, FBG, and HbA1C were significantly higher in men with type 2 diabetes compared to normoglycemic control (P<0.05). Multiple regression analysis showed SUA and age were associated with type 2 diabetes in women (P<0.05).

This study indicates that raised SUA levels are associated with the prevalence of type 2 diabetes in women, suggesting that SUA may be a predictive marker for the incidence of type 2 diabetes in the Korean women.

Nothing to Disclose: HC, GY, HK, IS, BC, DS

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm