Circulating Kisspeptin and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) do not Correlate with Gonadotropins Serum Levels

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 130-162-Neuroendocrinology
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-156
Aki Oride*1, Haruhiko Kanasaki2, Tselmeg Mijiddorj3, Unurjargal Sukhbaatar4 and Kohji Miyazaki5
1Shimane University, Izumo, Japan, 2Shimane Univ Sch of Med, Izumo, Japan, 3Shimane University School of Medicine, Izumo, Japan, 4Shimane University School of Medicine, Japan, 5Shimane Medical Univ, Shimane, Japan
Kisspeptins are known to be the principle regulators of the hypothalamic-pituitary gonadal (HPG) axis. In addition, the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of pituitary gonadotropins has been elucidated. We measured plasma concentrations of kisspeptin and PACAP and determined whether the levels of these peptides varied in proportion to circulating gonadotropin levels. Plasma LH levels were higher in postmenopausal women and in patients with premature ovarian failure (POF) and lower in patients with idiopathic hypogonadotropic hypogonadism (IHH) compared with the LH level in normally menstruating women. Similarly, serum FSH levels were higher in postmenopausal women and in patients with POF but lower in pregnant women and patients with IHH compared with normally menstruating women. Plasma levels of kisspeptins were significantly higher in pregnant women compared with normally menstruating women. However, no significant differences were observed in postmenopausal women, patients with POF, and patients with IHH. On the other hand, plasma levels of PACAP were significantly lower in pregnant women, patients with POF, and in IHH patients when compared with normally menstruating women. No significant differences were observed in PACAP concentration between postmenopausal women and in normally menstruating women. Our observations suggest that the serum levels of kisspeptins and PACAP did not correlate with variations in serum gonadotropin levels.

Nothing to Disclose: AO, HK, TM, US, KM

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