Session: SUN 72-87-HPA Axis
Poster Board SUN-82
Lean (BMI=20-25 kg/m2; n=19) and overweight/obese (BMI=27-35 kg/m2; n=17) men (50-70 years) were subjected to a well characterised psychological stress (Trier Social Stress Test; TSST)(2) at 3pm. Concentrations of cortisol and sAA were measured in saliva samples collected every 7-15min from 2pm-5pm. HR was measured using ECG around the same time points. Cortisol and sAA concentrations and HR were compared within and between groups using repeated measures ANOVA.
Mean (±SEM) BMI, body weight, percentage body fat (measured using bio-electrical impedance), resting systolic and diastolic blood pressures were significantly higher (p<0.05) in overweight/obese men compared to lean men (30.6±0.6 vs 23.5±0.3 kg/m2, 93.8±2.3 vs 69.7±1.6 kg, 30.6±0.6 vs 20.2±1.1 %, 129.0±2.8 vs 119.1±3.3 mmHg, 74.5±2.0 vs 67.7±2.1 mmHg, respectively). Both groups responded to the TSST with a substantial elevation of cortisol (406%), sAA (197%) and HR (22%) but this response did not differ significantly between lean and overweight/obese men (time * treatment for cortisol, sAA and HR; p=0.187, p=0.288, p=0.550, respectively). There were no significant differences between lean and overweight/obese men in pre-treatment values, peak height, reactivity or area under the curve for cortisol, sAA or HR (p>0.05 for all).
While both groups had substantial responses to psychological stress, the results did not support the hypothesis that overweight/obese men will have a greater cortisol, sAA and HR responses to psychological stress compared to lean men. This suggests that elevated hypothalamo-ptuitary adrenal axis (measured by cortisol) and sympatho-adrenal medullary system (measured by sAA and HR) responses to acute psychological stress may not be a major mechanism that increases the risk of overweight/obese men developing stress-related disease.
Nothing to Disclose: SUJ, SJT, ET, CAN, AJT, AIT
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