Alarming results of vitamin D status among adults in Latvia

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-260
Ingvars Rasa*1 and Maija Mukane2
1Latvian Osteoporosis and Bone Metabolic Diseases Association, Riga, Latvia, 2Riga Stradins University, Riga, Latvia
Background:Vitamin D insufficiency/deficiency is worldwide common, including Europe. It linked to skeletal and extra–skeletal pathologic states. Latvia stands on latitude 56° N, and there is no dairy product fortification with vitamin D. Due to those facts there is an expectation of vitamin D insufficiency/deficiency high prevalence in the population.

Aim:To determine the vitamin D status among adults in Latvia.

Methods:Retrospective study from January, 2010 till November, 2011, which involve randomly selected data, of 4809 adults, taken from Central Laboratory Ltd electronic database. 25(OH)D3 determined with Cobas e411, Roche Diagnostics (Germany). 25(OH)D3 sufficient concentration defined as >30 ng/ml, insufficiency as 20–29 ng/ml and deficiency as <19 ng/ml. To determine seasonal 25(OH)D3concentration differences astronomical seasons applied. SPSS 17 used for statistical analysis.

Results:4330 female patients (pts) (90%) and 479 male pts (10%) included. The mean age of women was 60.3±14.5 years (yrs) and men – 54.2±17.9 yrs (p<0.001). The median serum 25(OH)D3 concentration obtained from all data was 18.4 ng/ml (interquartile range [IQR], 11.8–26.7 ng/ml). The median concentration in women was 18.5 ng/ml (IQR, 11.8–26.7 ng/ml) and in men 17.8 ng/ml (IQR, 11.2–26.7 ng/ml) (p=0.159). Low levels of 25(OH)D3 seen in 82.1% of the study population, from which 55.3% were deficient, and 26.8% were insufficient. Only 17.8% of the sample group had sufficient 25(OH)D3 concentration. Analyzing winter and summer periods 2010–2011 the median serum 25(OH)D3 concentration in winter was 12.3 ng/ml (IQR, 8.1–17.1 ng/ml) and in summer was 21.6 ng/ml (IQR, 14.7–29.0 ng/ml) (p<0.001). There is a significant difference between the median concentration obtained from all data and the median serum concentration in all summer or winter periods (p<0.001). In 2010, the mean serum winter 25(OH)D3 concentration was 13.4 ng/ml (IQR, 7.4–20.7 ng/ml), in 2011 – 12.0 ng/ml (IQR, 8.2–15.9 ng/ml) (p<0.001). In 2010, the mean serum summer concentration was 19.6 ng/ml (IQR, 14.3 – 24.7 ng/ml), in 2011 – 22.9 ng/ml (IQR, 14.9–31.48 ng/ml) (p<0.001). In the 18–49 yrs age group women had the median serum 25(OH)D3 concentration 18.7 ng/ml (IQR, 11.8–26.6 ng/ml) and men had 17.9 ng/ml (IQR, 11.1–25.7 ng/ml). In the 50–69 yrs group women had the median serum 25(OH)D3 concentration 18.6 ng/ml (IQR, 12.0–26.7 ng/ml) and men had 16.9 ng/ml (10.7–25.3 ng/ml). In the ≥70 yrs group women had average serum 25(OH)D3 concentration 18.9 ng/ml (IQR, 11.3–26.7 ng/ml) and men had 19.0 ng/ml (IQR, 12.9–26.0 ng/ml). There is no significant difference in serum 25(OH)D3concentration between age groups (p=0.783).

Conclusions:The study results show high prevalence of D vitamin insufficiency/deficiency throughout the year in the study population without vitamin D dairy fortification living in Latvia at the latitude 56° N.

Nothing to Disclose: IR, MM

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