Accumulative effect of exposure to heavy metals on metabolic syndrome in the Korean population: The Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 366-382-Physiological Impacts of Endocrine Disrupting Chemicals
Basic/Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-373
Seong Su Moon*1, Young-Sil Lee2 and Tae Kyoon Kim3
1Dongguk University College of Medicine, Gyeongju, South Korea, 2Dongguk University College of Medicine, 3Pusan Paik Hospital, College of Medicine, Inje University
There have been increasing concerns regarding health problems due to endocrine disrupting chemicals (EDCs). We investigated association of heavy metals, including lead, mercury, and cadmium, with metabolic syndrome (MS) and its individual components in the Korean population. Participants included 2160 males and 2186 females 10 years of age or older from the fourth and fifth Korea National Health and Nutritional Examination Surveys of the Korean population (2009 and 2010). We examined the relationship of blood lead, mercury, and cadmium levels with MS and their cumulative effect on MS after adjustment for age, sex, body mass index (BMI), region, smoking, alcohol consumption, and regular exercise. Lead showed a significant but modest association with prevalence of MS. Other heavy metals did not show such a relationship with MS. Of particular interest, cumulative effect of a mixture of heavy metals on prevalence of MS was stronger than the sum of effect of each heavy metal. Compared with those in the lowest quartile of sum of heavy metals, participants in the highest quartile had an odds ratio for MS of 1.556 (95% confidence interval = 1.134-2.134; P for trend = 0.008). Among components of MS, significant relationship of the sum of heavy metals with hypertension and elevated triglyceride was demonstrated. In conclusion, accumulation of heavy metals, such as lead, mercury, and cadmium in the body has shown a significant association with MS. Accumulative effect of exposure to heavy metals could be more additive or synergistic than individual exposure in the general population.

Nothing to Disclose: SSM, YSL, TKK

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