Women with Polycystic Ovary Syndrome Demonstrate Improved Fasting and 2-hour Insulin Following 8-Week Low Starch/Low Dairy Diet

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 834-867-Islet Biology
Bench to Bedside
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-864
Jennifer Lynn Phy*1, Ali Pohlmeier2, Zainab Al-Ibraheemi3, Jamie Cooper2, Kitty Harris2 and Mallory Boylan2
1Texas Tech University Health Sciences Center, Lubbock, TX, 2Texas Tech University, 3Texas Tech University Health Sciences Center
Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with oligomenorrhea, hyperandrogenism, and frequently insulin resistance. Women with PCOS are at increased risk of diabetes, obesity, hyperlipidemia and cardiovascular disease. Hyperinsulinemia exacerbates these risks. Emerging research shows that dairy products and foods high in carbohydrates from starch increase post-prandial insulinogenic effects. The aim of this study was to evaluate the effect of an 8-week low-insulinogenic diet on fasting and 2-hour serum insulin levels in women with PCOS.

Participants and Methods Used: Eleven obese women with PCOS (age 29.6±4.5 years, BMI 38.5±5.9 kg/m2) completed an oral glucose tolerance test (OGTT) to measure change in fasting and 2-hour insulin before and after 8 weeks on a low-insulinogenic diet. Exclusion criteria included previous diagnosis of diabetes, history of eating disorder, or history of surgical weight loss procedure. Participants previously taking metformin, cyclic progesterone or oral contraceptive pills discontinued these medications for at least one month prior to participation in the study. Participants received verbal and written dietary instructions and were permitted to eat to the point of satiety. No calorie or carbohydrate counting was required. Participants did not increase their exercise frequency or intensity above their baseline. 

Results: After 8 weeks on a low-insulinogenic diet, subjects lost an average of 8.3±2.3 kg despite the fact that this was not designed as a weight loss diet. A battery of normality tests suggested that change in fasting insulin was normally distributed (p>0.25) and proved that change in 2-hour insulin is not normally distributed (p<0.01).  Fasting and 2-hour insulin decreased from 31.6±12.1 pmol/L to 17.1±5.3 (Paired T = -4.882, p<.001) and 279.3±284.9 to 144.9±91.2 (Wilcoxon’s S = -24, p<.05) from pre- to post-diet, respectively.

Conclusions: Obese women with PCOS had elevated serum insulin levels demonstrated by elevated fasting and 2-hour insulin after OGTT prior to dietary intervention.  The significant change in fasting and 2-hour insulin after 8 weeks of dietary modification supports the need for further research using dietary intervention to reduce consumption of insulinogenic foods in an effort to reduce hyperinsulinemia. The weight loss achieved by study participants is encouraging.

Nothing to Disclose: JLP, AP, ZA, JC, KH, MB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Laura W. Bush Institute for Women's Health/University Medical Center Women's Health Research Scholar Grant