Session: SAT 834-867-Islet Biology
Bench to Bedside
Poster Board SAT-864
Participants and Methods Used: Eleven obese women with PCOS (age 29.6±4.5 years, BMI 38.5±5.9 kg/m2) completed an oral glucose tolerance test (OGTT) to measure change in fasting and 2-hour insulin before and after 8 weeks on a low-insulinogenic diet. Exclusion criteria included previous diagnosis of diabetes, history of eating disorder, or history of surgical weight loss procedure. Participants previously taking metformin, cyclic progesterone or oral contraceptive pills discontinued these medications for at least one month prior to participation in the study. Participants received verbal and written dietary instructions and were permitted to eat to the point of satiety. No calorie or carbohydrate counting was required. Participants did not increase their exercise frequency or intensity above their baseline.
Results: After 8 weeks on a low-insulinogenic diet, subjects lost an average of 8.3±2.3 kg despite the fact that this was not designed as a weight loss diet. A battery of normality tests suggested that change in fasting insulin was normally distributed (p>0.25) and proved that change in 2-hour insulin is not normally distributed (p<0.01). Fasting and 2-hour insulin decreased from 31.6±12.1 pmol/L to 17.1±5.3 (Paired T = -4.882, p<.001) and 279.3±284.9 to 144.9±91.2 (Wilcoxon’s S = -24, p<.05) from pre- to post-diet, respectively.
Conclusions: Obese women with PCOS had elevated serum insulin levels demonstrated by elevated fasting and 2-hour insulin after OGTT prior to dietary intervention. The significant change in fasting and 2-hour insulin after 8 weeks of dietary modification supports the need for further research using dietary intervention to reduce consumption of insulinogenic foods in an effort to reduce hyperinsulinemia. The weight loss achieved by study participants is encouraging.
Nothing to Disclose: JLP, AP, ZA, JC, KH, MB
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