Session: SAT 532-553-Hyperandrogenic Disorders
Poster Board SAT-533
Serum AMH levels were measured in 1.465 patients with normogonadotropic, normoestrogenic anovulation, and compared with AMH levels in 468 age-matched healthy controls. 1.289 (88.0%) Patients had PCOS according to the Rotterdam consensus criteria.
Serum AMH levels in the total cohort of patients were significantly higher than in controls (P < 0.001), although in 80% of anovulatory women AMH levels were within the normal range. Patients had two- to three-fold more follicles than controls (P < 0.001). In agreement, 83.0% of the anovulatory women had PCOM. Serum AMH and AFC were positively correlated (r = + 0.62; P < 0.001). Receiver operating characteristic (ROC) curve analysis was performed to test the diagnostic accuracy of AMH for the presence of PCOM. The area under the curve was 89.8 % (confidence interval 87.9 – 91.7 %). In this ROC analysis, only a selection of control subjects was included, i.e. those with normal ovarian morphology. Consequently, the selected control subjects did not represent the age range of the total patient cohort.
In conclusion, the majority of our large cohort of normogonadotropic anovulatory patients had serum AMH levels within the normal range. In addition, our data suggest that the threshold level to discriminate PCOM from normal ovarian morphology, is age-dependent and that the threshold for PCOM might need to be adjusted. Consequently, the criteria for PCOS according to the Rotterdam criteria might need refinement.
Nothing to Disclose: SL, IS, OV, FHD, JAV
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