Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Poster Board SUN-266
Methods. We studied 497 women and 505 men 70 years or older of Prospective Study of the Vasculature in Uppsala Seniors Study (PIVUS), with complete data on endothelial function, endothelium-independent vasodilation (EIDV), vitamin D and SHBG. Endothelium-dependent vasodilation (EDV) was assessed by invasive forearm technique with acetylcholine, flow-mediated vasodilation (FMD) and the pulse wave analysis (reflection index, RI). Vitamin D was measured by chemiluminescent immunoassay technology. The coefficient of variation for interassay analyses is 18.4% at a 25-OH D level of 39.5 nmol/L and 11.7% at 121.25 nmol/L.Multivariate regression analysis adjusted for multiple confounders was used to assess the relationship between vitamin D and endothelial function.
Results. In men, but not in women, we found a positive relationship between vitamin D and EIDV after adjustment for BMI (β±SE= 1.41±0.54, p=0.01), and further adjustment for fasting insulin, smoking, C Reactive protein, HDL cholesterol, diabetes, hypertension, medications, SHBG and sex hormones (β±SE=1.94±0.61, p=0.017). No relationship was found between vitamin D and EDV, FMD, RI and EIDV in both sexes.
Conclusions. In older men, but not in women, vitamin D is positively and independently associated with endothelium-independent vasodilation. Further studies are needed to evaluate the role of vitamin D in endothelial function in older population.
Nothing to Disclose: MM, FL, CC, AA, RA, MM, FD, ES, GB, GS, MP, GP, GL, TC, LL, GC
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