VITAMIN D LEVELS AND ENDOTHELIUM VASODILATION IN OLDER SUBJECTS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Basic/Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-266
Marcello Maggio*1, Fulvio Lauretani2, Chiara Cattabiani3, Andrea Artoni1, Rosalia Aloe4, Marco Mantovani5, Francesca De Vita6, Eleonora Sutti7, Giuliana Bondi5, Giulia Schiavi6, Mario Pedrazzoni7, Giovanni Passeri7, Giuseppe Lippi4, Tommy Cederholm8, Lars Lind9 and Gianpaolo Ceda1
1University of Parma, Parma, Italy, 2University-Hospital of Parma, 3University of Parma, Italy, Parma, Italy, 4Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy., PARMA, 5University of Parma, Italy, PARMA, Italy, 6University of Parma, Italy, 7University of Parma, Italy, PARMA, 8Department of Public Health and Caring Sciences, Section of Clinical Nutrition and Metabolism, 9Uppsala University Hospital, Uppsala, Sweden
Vitamin D has been shown as important determinant of physical and muscle function  in older  individuals. One the potential mechanisms underlying the relationship between vitamin D and physical function is the modulation of endothelial function, given the presence of vitamin D receptor at this level. However, the relationship between vitamin D levels and endothelial function has never been addressed in a study population of older individuals.

Methods. We studied 497  women and 505 men 70 years or older of Prospective Study of the Vasculature in Uppsala Seniors Study (PIVUS), with complete data on endothelial function, endothelium-independent vasodilation (EIDV), vitamin D and SHBG. Endothelium-dependent vasodilation (EDV) was assessed by invasive forearm technique with acetylcholine, flow-mediated vasodilation (FMD) and the pulse wave analysis (reflection index, RI). Vitamin D  was measured by chemiluminescent immunoassay technology. The coefficient of variation for interassay analyses is 18.4% at a 25-OH D level of 39.5  nmol/L and 11.7% at 121.25 nmol/L.Multivariate regression analysis adjusted for multiple confounders was used to assess the relationship between vitamin D and endothelial function.

Results. In men, but not in women, we found a positive relationship between vitamin D and EIDV after adjustment for BMI  (β±SE= 1.41±0.54, p=0.01), and further adjustment for fasting  insulin, smoking, C Reactive protein, HDL cholesterol, diabetes, hypertension, medications, SHBG  and sex hormones (β±SE=1.94±0.61, p=0.017).  No relationship was found between vitamin D and EDV, FMD, RI and EIDV in both sexes.

Conclusions. In older men, but not in women, vitamin D is positively and independently associated with endothelium-independent vasodilation. Further studies are needed to evaluate the role of vitamin D  in endothelial function  in older population.

Nothing to Disclose: MM, FL, CC, AA, RA, MM, FD, ES, GB, GS, MP, GP, GL, TC, LL, GC

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm