Session: OR46-Hyperandrogenemia: Influences & Implications
Room 121 (Moscone Center)
Thirty women with PCOS, defined using the NIH criteria, were enrolled in a cross-over diet intervention study. Two eucaloric (weight-maintaining) diets were administered for 8 weeks in random order, separated by a 4-week wash-out period. One diet, the “Standard” (STD) diet, was 55% energy from CHO, 18% energy from protein, and 27% energy from fat. The other diet, the lower-CHO diet, had a macronutrient composition of 41:19:40. Energy requirements were determined by indirect calorimetery, with an activity factor of 1.35.
β-cell responsiveness was assessed using mathematical modeling as the C-peptide response to glucose during a liquid meal test. Insulin sensitivity was determined using insulin and glucose values throughout the meal test. Insulin resistance was determined as HOMA-IR. Total testosterone was assessed by immunoassay, and the lipid profile with a clinical analyzer using standard biochemical methods.
Paired t-test indicated that the lower-CHO diet induced significant decreases in basal β-cell response (PhiB), fasting insulin, fasting glucose, HOMA-IR, and all cholesterol measures, and significant increases in insulin sensitivity and dynamic (“first phase”) β-cell response; total testosterone decreased by 24% (P=0.05). The STD diet induced a decrease in HOMA-IR and an increase in the total cholesterol-to-HDL-C ratio. Across all data combined, the change in testosterone was positively associated with the changes in fasting insulin, PhiB, and insulin AUC (P<0.05).
In conclusion, in women with PCOS, modest reduction in dietary CHO in the context of a weight-maintaining diet has numerous beneficial effects on the metabolic profile that may lead to a decrease in circulating testosterone.
R01HD054960, UL1RR025777, P30DK56336, P60DK079626
Nothing to Disclose: BAG, PCC, FO, LLTG, RA, RD, WG, AMG, GWB
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